ADRIANA | α2B adrenoceptor antagonist
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $80.00 | ||
| 25 mg | $285.00 |
ADRIANA (719277-27-7) is potent antagonist (IC50 = 1.71 µM) of the α2B adrenoceptor with selectivity over α2A and α2C. It promotes noradrenaline release in the murine spinal dorsal horn leading to potent analgesic effects via stimulation of the α2A-dependent pain inhibitory pathway. Active in various nociceptive pain models in both mice and non-human primates. Orally bioavailable with no adverse cardiac/circulatory system effects.
References/Citations:
- Toyomoto et al. (2025), Discovery and development of an oral analgesic targeting the α2B adrenoceptor; Proc. Natl. Acad. Sci. USA 122 e2500006122
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
ADRIANA (719277-27-7) is potent antagonist (IC50 = 1.71 µM) of the α2B adrenoceptor with selectivity over α2A and α2C. It promotes noradrenaline release in the murine spinal dorsal horn leading to potent analgesic effects via stimulation of the α2A-dependent pain inhibitory pathway. Active in various nociceptive pain models in both mice and non-human primates. Orally bioavailable with no adverse cardiac/circulatory system effects.
References/Citations:
- Toyomoto et al. (2025), Discovery and development of an oral analgesic targeting the α2B adrenoceptor; Proc. Natl. Acad. Sci. USA 122 e2500006122
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