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Product Details

Afatinib | EGFR and HER2 inhibitor

Afatinib (850140-72-6) is a clinically useful kinase inhibitor approved for the treatment of non-small cell lung cancer. It is a potent and highly selective inhibitor of mutant and wild-type EGFR (IC50= 0.5 nM) and HER2 (IC50 = 14 nM).

References/Citations

1) Li et al. (2008), BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models; Oncogene, 27 4702

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Focus Biomolecules cell signaling supplier, chemical structure of Afatinib | EGFR, HER2 inhibitor | CAS 850140-72-6

Catalog#  10-4510

$85.00
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CAS:
850140-72-6
Catalog Number:
10-4510
Activity:
EGFR and HER2 inhibitor
Chemical Name:
N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4(dimethylamino)-2E-butenamide
Alternate Names:
BIBW2992
Molecular Weight:
485.94
Molecular Formula:
C24H25ClFN5O3
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
Physical Properties:
Pale yellow solid
Purity:
99% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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