my account
Login
  Loading... Please wait...

Product Details

AG-1517 HCl | Tyrosine kinase inhibitor

AG-1517 HCl (153436-54-5) is an ultra-potent inhibitor of epidermal growth factor receptor tyrosine kinase (EGFR), with an IC50 of 25 pM. Inhibits other tyrosine kinases at micromolar or higher concentrations. It selectively blocks EGF-mediated cellular processes including mitogenesis, early gene expression and oncogenic transformation.1 Inhibits the growth of a number of cancer cell lines.2 AG-1517 HCl is an extremely useful tool for exploring EGF-mediated cellular signaling.3

References/Citations
1) Fry et al. (1994), A specific inhibitor of the epidermal growth factor receptor tyrosine kinase; Science, 265 1093
2) Bos et al. (1997), PD153035, a tyrosine kinase inhibitor, prevents epidermal growth factor receptor activation and inhibits growth of cancer cells in a receptor number-dependent manner; Clin. Cancer Res., 3 2099
3) Tetreault et al. (2008), Specific signaling cascades involved in cell spreading during healing of micro-wounded gastric epithelial monolayers; J. Cell. Biochem., 105 1240

swipe
AG-1517 HCl | 153436-54-5 | Structure | Supplier

Catalog#  10-1377

$70.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
Request Bulk Quote
CAS:
153436-54-5
Catalog Number:
10-1377
Activity:
Tyrosine kinase inhibitor
Alternate Names:
PD153,053; SU-5271; Z-252868
Chemical Name:
4-(3-Bromoanilino)-6,7-dimethoxyquinazoline hydrochloride
Molecular Weight:
360.21
Molecular Formula:
C16H14BrN3O2
Solubility:
Soluble in DMSO (up to 5 mg/ml).
Physical Properties:
white or off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

Connect with Focus

Click the button below to add the AG-1517 HCl | Tyrosine kinase inhibitor to your wish list.