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AG-1517 HCl | Tyrosine kinase inhibitor

AG-1517 HCl (153436-54-5) is an ultra-potent inhibitor of epidermal growth factor receptor tyrosine kinase (EGFR), with an IC50 of 25 pM. Inhibits other tyrosine kinases at micromolar or higher concentrations. It selectively blocks EGF-mediated cellular processes including mitogenesis, early gene expression and oncogenic transformation.1 Inhibits the growth of a number of cancer cell lines.2 AG-1517 HCl is an extremely useful tool for exploring EGF-mediated cellular signaling.3

1) Fry et al. (1994), A specific inhibitor of the epidermal growth factor receptor tyrosine kinase; Science, 265 1093
2) Bos et al. (1997), PD153035, a tyrosine kinase inhibitor, prevents epidermal growth factor receptor activation and inhibits growth of cancer cells in a receptor number-dependent manner; Clin. Cancer Res., 3 2099
3) Tetreault et al. (2008), Specific signaling cascades involved in cell spreading during healing of micro-wounded gastric epithelial monolayers; J. Cell. Biochem., 105 1240

Focus Biomolecules supplier, chemical structure of AG-1517 HCl | Tyrosine kinase inhibitor | CAS 153436-54-5

Catalog#  10-1377

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Catalog Number:
Tyrosine kinase inhibitor
Alternate Names:
PD153,053; SU-5271; Z-252868
Chemical Name:
4-(3-Bromoanilino)-6,7-dimethoxyquinazoline hydrochloride
Molecular Weight:
Molecular Formula:
Soluble in DMSO (up to 5 mg/ml).
Physical Properties:
white or off-white solid
98% by TLC
NMR (Conforms)
Storage Temperature:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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