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AI-1 | Nrf2 activator

AI-1 (75483-04-4) is a novel antioxidant response element (ARE) activator which activates Nrf2 by covalently modifying Keap1 (Kelch-like ECH-associated protein 1) a negative regulator of Nrf2. Modification of Cys151 of Keap1 by AI-1 disrupts the ability of Keap1 to searve as an adaptor for Cul3-Keap1 ubiquitin ligase complex, thereby stabilizing and inducing transcriptional activation of Nrf2. AI-1 is a useful pharmacological tool for probing the involvement of Nrf2 in cellular physiology1. Cell permeable.

References/Citations
1) Hur et al. (2010), A small-molecule inducer of the antioxidant response element; Chem. Biol., 17 537

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Focus Biomolecules cell signaling reagent supplier, chemical structure of AI-1 | Nrf2 activator | CAS 75483-04-4

Catalog#  10-1471

$70.00
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Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
75483-04-4
Catalog Number:
10-1471
Activity:
Nrf2 activator
Chemical Name:
4-Chloro-1,2-dihydro-1-methyl-2-oxo-3-quinolinecarboxylic acid ethyl ester
Molecular Weight:
265.70+L277
Molecular Formula:
C13H12ClNO3
Solubility:
Soluble in DMSO (up to 15 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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