ALLM | Calpain inhibitor

CAS:
136632-32-1
Catalog Number:
10-1349
Activity:
Calpain inhibitor
Chemical Name:
N-Acetyl-Leu-Leu-Methional
Alternate Names:
Ac-LLM-CHO
Molecular Weight:
401.56
Molecular Formula:
C19H35N3O4S
Solubility:
Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to 5 mg/ml).
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Available Options

Size :PriceQuantity 
5 mg$60.00
25 mg$175.00
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ALLM (136632-32-1) is a cell-permeable, peptide aldehyde inhibitor of calpain (calpain I, Ki = 120 nM, calpain II, Ki = 230 nM) and other neutral cysteine proteases. Potent inhibitor of cathepsin L (Ki=0.6 nM) and cathepsin B (Ki=100 nM).1 Weak inhibitor of the chymotrypsin-like activity of the proteasome.2 Cell permeable.

References/Citations:

1) Sasaki et al. (1990), Inhibitory effect of di- and tripeptidyl aldehydes on calpains and cathepsins; J. Enzyme Inhib., 3 195
2) Vinitsky et al. (1992), Inhibition of the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex; Biochemistry, 31 9421

CAS:
136632-32-1
Catalog Number:
10-1349
Activity:
Calpain inhibitor
Chemical Name:
N-Acetyl-Leu-Leu-Methional
Alternate Names:
Ac-LLM-CHO
Molecular Weight:
401.56
Molecular Formula:
C19H35N3O4S
Solubility:
Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to 5 mg/ml).
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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