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Product Details

ALLN | Calpain inhibitor

ALLN (110044-82-1) is a cell-permeable, peptide aldehyde inhibitor of calpain I (Ki=190 nM), calpain II (Ki=150 nM), cathepsin L (Ki=0.5 nM) and other neutral cysteine proteases.1 Inhibits cell cycle progression at G1/S and metaphase/anaphase in CHO cells by inhibiting cyclin B degradation.2 Inhibits proteolytic degradation of IκBα and IκBβ in RAW macrophages induced with LPS.3 Blocks AIF-mediated necroptosis.4 Cell permeable.

References/Citations

1) Sasaki et al. (1990), Inhibitory effect of di- and tripeptidyl aldehydes on calpains and cathepsins; J. Enzyme Inhib. 3 195
2) Sherwood et al. (1993) In vivo inhibition of cyclin B degradation and induction of cell-cycle arrest in mammalian cells by the neutral cysteine protease inhibitor N-acetylleucylleucylnorleucinal; Proc. Natl. Acad. Sci USA 90 3353
3) Schow and Joly (1997), N-acetyl-leucinyl-leucinyl-norleucinal inhibits lipopolysaccharide-induced NF-kappaB activation and prevents TNF and IL-6 synthesis in vivo; Cell Immunol. 175 199
4) Shang et al. (2014) Calpain: a molecule to induce AIF-mediated necroptosis in RGC-5 following elevated hydrostatic pressure; BMC Neurosci. 15 63

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Focus Biomolecules cell signaling reagent supplier, chemical structure of ALLN | Calpain inhibitor | CAS 110044-82-1

Catalog#  10-3024-0005

$50.00
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CAS:
110044-82-1
Catalog Number:
10-3024
Activity:
Calpain inhibitor
Chemical Name:
Ac-Leu-Leu-Nle-CHO
Alternate Names:
Ac-LL-norleucinal
Molecular Weight:
383.53
Molecular Formula:
C20H37N3O4
Solubility:
Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to 5 mg/ml)
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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