AM80 | RARα agonist

CAS:
 94497-51-5
Catalog Number:
 10-2534
AM80 chemical structure

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AM80 (94497-51-5) is a  retinoic acid receptor α (RARα) agonist that induces differentiation (ED50 = 0.79 nM) and apoptosis of HL-60 cells.1 Exhibits antiproliferative effects against a variety of human tumor cells lines (mean values of 35, 40 and 60% growth inhibition at 0.1, 1 and 10 μM respectively).2  It ameliorates chronic graft-versus-host disease by down-regulating Th1 and Th17.3 AM80 induces neuronal differentiation in a human neuroblastoma NH-12 cell line.4 Pulmonary administration of AM80 regenerates collapsed alveoli.5

References/Citations:

  1. Kagechika et al. (1988), Retinobenzoic acids. 1. Structure-activity relationships of aromatic amides with retinoidal activity; J. Med. Chem., 31 2182
  2. Jimi et al. (2007), RARalpha is a regulatory factor for Am-80-induced cell growth inhibition of hematologic malignant cells; Int. J. Oncol., 31 397
  3. Nishimori et al. (2012), Synthetic retinoid Am80 ameliorates chronic graft-versus-host disease by down-regulating Th1 and Th17; Blood, 119 285
  4. Shiohira et al. (2010), Am80 induces neuronal differentiation in a human neuroblastoma NH-12 cell line; Int. J. Mol. Med., 26 393
  5. Sakai et al. (2014), Pulmonary administration of Am80 regenerates collapsed alveoli; Control. Release, 196 154
94497-51-5, AM-80, AM80, AM80 supplier, NSC608000, Retinobenzoic acid, Tamibarotene
CAS:
94497-51-5
Catalog Number:
10-2534
Activity:
RARα agonist
Chemical Names:
4-[[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)amino]-carbonyl]benzoic acid
Alternate Name:
Tamibarotene; NSC608000; Retinobenzoic acid
Molecular Weight:
351.45
Molecular Formula:

C22H25NO3

Solubility:
Soluble in DMSO (50 mg/ml); Ethanol (18 mg/ml)
Physical Properties:
White solid
Purity:

>98% HPLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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AM80 (94497-51-5) is a  retinoic acid receptor α (RARα) agonist that induces differentiation (ED50 = 0.79 nM) and apoptosis of HL-60 cells.1 Exhibits antiproliferative effects against a variety of human tumor cells lines (mean values of 35, 40 and 60% growth inhibition at 0.1, 1 and 10 μM respectively).2  It ameliorates chronic graft-versus-host disease by down-regulating Th1 and Th17.3 AM80 induces neuronal differentiation in a human neuroblastoma NH-12 cell line.4 Pulmonary administration of AM80 regenerates collapsed alveoli.5

References/Citations:

  1. Kagechika et al. (1988), Retinobenzoic acids. 1. Structure-activity relationships of aromatic amides with retinoidal activity; J. Med. Chem., 31 2182
  2. Jimi et al. (2007), RARalpha is a regulatory factor for Am-80-induced cell growth inhibition of hematologic malignant cells; Int. J. Oncol., 31 397
  3. Nishimori et al. (2012), Synthetic retinoid Am80 ameliorates chronic graft-versus-host disease by down-regulating Th1 and Th17; Blood, 119 285
  4. Shiohira et al. (2010), Am80 induces neuronal differentiation in a human neuroblastoma NH-12 cell line; Int. J. Mol. Med., 26 393
  5. Sakai et al. (2014), Pulmonary administration of Am80 regenerates collapsed alveoli; Control. Release, 196 154

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