ANP-230 | Nav1.7, 1.8, and 1.9 blocker

CAS:
 1233231-30-5
Catalog Number:
 10-3991

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ANP-230 (1233231-30-5) is a state-independent selective inhibitor of sodium channels Nav1.7, 1.8, and 1.9 (IC50’s respectively: 7.1 µM, 11.4 µM, and 6.7 µM).1 Selective over the cardiac Nav1.5 channel (IC50 = 156 µm). It potently reduced neuronal excitability in rat DRG neurons.3 ANP-230 reduced pain sensitivity in a mouse episodic pain syndrome model.2 It demonstrated efficacy in several models of neuropathic and inflammatory pain with no motor function impairment.3 It also potentiated the anti-allodynic effects of pregabalin and morphine when administered concurrently.3

References/Citations:

  1. Kamei et al. (2024), Unique electrophysiological property of a novel Nav1.7, Nav1.8, and Nav1.9 sodium channel blocker, ANP-230; Biochem. Biophys. Res. Commun., 721 150126
  2. Okuda et al. (2023), Reduced pain sensitivity of episodic pain syndrome model mice carrying a Nav1.9 mutation by ANP-230, a novel sodium channel blocker; Heliyon, 9 e15423
  3. Kamei al. (2025), A novel Nav1.7, Nav1.8, and Nav1.9 blocker, ANP-230, has broad analgesic efficacy in preclinical models with favorable safety margins; Biochem. Biophys. Res. Commun., 777 152197
1233231-30-5, ANP-230, ANP-230 supplier, ANP230, DSP-2230, DSP2230, Nav1.7 blocker, NaV1.8 blocker, Nav1.9 blocker, sodium channel blocker
CAS:
1233231-30-5
Catalog Number:
10-3991
Activity:
Nav1.7, 1.8, and 1.9 blocker
Chemical Names:
(2S)-2-[[3-Cyclobutyl-5-(3,4,5-trifluorophenoxy)imidazo[4,5-b]pyridin-2-yl]methylamino]propanamide
Alternate Name:
DSP-2230
Molecular Weight:
419.41
Molecular Formula:

C20H20F3N5O2

Solubility:
Soluble in DMSO (20 mg/ml)
Physical Properties:
White solid
Purity:

98% HPLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

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Product Data Sheet:

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ANP-230 (1233231-30-5) is a state-independent selective inhibitor of sodium channels Nav1.7, 1.8, and 1.9 (IC50’s respectively: 7.1 µM, 11.4 µM, and 6.7 µM).1 Selective over the cardiac Nav1.5 channel (IC50 = 156 µm). It potently reduced neuronal excitability in rat DRG neurons.3 ANP-230 reduced pain sensitivity in a mouse episodic pain syndrome model.2 It demonstrated efficacy in several models of neuropathic and inflammatory pain with no motor function impairment.3 It also potentiated the anti-allodynic effects of pregabalin and morphine when administered concurrently.3

References/Citations:

  1. Kamei et al. (2024), Unique electrophysiological property of a novel Nav1.7, Nav1.8, and Nav1.9 sodium channel blocker, ANP-230; Biochem. Biophys. Res. Commun., 721 150126
  2. Okuda et al. (2023), Reduced pain sensitivity of episodic pain syndrome model mice carrying a Nav1.9 mutation by ANP-230, a novel sodium channel blocker; Heliyon, 9 e15423
  3. Kamei al. (2025), A novel Nav1.7, Nav1.8, and Nav1.9 blocker, ANP-230, has broad analgesic efficacy in preclinical models with favorable safety margins; Biochem. Biophys. Res. Commun., 777 152197

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