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Product Details

Ansamitocin P3 | Microtubule depolymerizer

Ansamitocin P3 (66547-09-9) is a fungal metabolite from Actinosynnema pretiosum which binds to the phomopsin A/rhizoxin site on tubulin.1,2 Ansamitocin P3 is a maytansine analog which displays potent cytotoxicity against various human tumor cell lines.2,3 Maytansine and its analogs cause extensive disassembly of microtubules and totally prevent tubulin spiralization.4

References/Citations
1) Li et al (1992) Binding selectivity of rhizoxin, phomopsin A, vinblastine and ansamitocin P-3 to fungal tubulins: differential interactions of thes antimitotic agents with brain and fungal tubulins; Biochem. Biophys. Res. Commun., 187 722
2) Venghateri et al. (2013) Ansamitocin P3 Depolymerizes Microtubules and Induces Apoptosis by Binding Tubulin at the Vinblastine Site; PLoS ONE 8 e75182
3) Suwanborirux et al. (1990) Ansamitocin P-3, a maytansinoid, from claopodium crispifolium and anomodo attenuates or associated actinomycetes; Experientia, 46 117
4) Ootsu et al. (1980) Effects of new antimitotic antibiotics, ansamitocins, on the growth of murine tumors in vivo and on the assembly of microtubules in vitro; Cancer Res. 40 1707

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Focus Biomolecules supplier, chemical structure of Ansamitocin P3 | Microtubule depolymerizer | CAS 66547-09-9

Catalog#  10-2199

$50.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
66547-09-9
Catalog Number:
10-2199
Activity:
Microtubule depolymerizer
Molecular Weight:
635.16
Molecular Formula:
C32H43ClN2O9
Solubility:
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 30 mg/ml with warming).
Physical Properties:
White solid
Purity:
>90% by TLC, remainder is P-1, P-2 and P-4.
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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