Ansatrienin b (82189-04-6) represents a novel class of ansamycins.¹ Inhibits osteoclastic bone resorption.² Potentiates the activity of several clinically useful antitumor agents.³ Translation inhibitor which prevents ICAM-1 expression induced by pro-inflammatory cytokines.⁴

References/Citations

1) Sugita et al. (1982), Studies on mycotrienin antibiotics, a novel class of ansamycins. II. Structure elucidation and biosynthesis of mycotrienins I and II; J. Antibiot. (Tokyo), 35 1467
2) Feuerbach et al. (1995), Mycotrienins. A new class of potent inhibitors of osteoclastic bone resorption; J. Biol. Chem., 270 25949
3) Yamada et al. (2011), Mycotrienin II, a translation inhibitor that prevents ICAM-1 expression induced by pro-inflammatory cytokines; J. Antibiot. (Tokyo), 64 361