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Ansatrienin B | Cytotoxic activity

Ansatrienin b (82189-04-6) represents a novel class of ansamycins.1 Inhibits osteoclastic bone resorption.2 Potentiates the activity of several clinically useful antitumor agents.3 Translation inhibitor which prevents ICAM-1 expression induced by pro-inflammatory cytokines.4

References/Citations

1) Sugita et al. (1982), Studies on mycotrienin antibiotics, a novel class of ansamycins. II. Structure elucidation and biosynthesis of mycotrienins I and II; J. Antibiot. (Tokyo), 35 1467
2) Feuerbach et al. (1995), Mycotrienins. A new class of potent inhibitors of osteoclastic bone resorption; J. Biol. Chem., 270 25949
3) Yamada et al. (2011), Mycotrienin II, a translation inhibitor that prevents ICAM-1 expression induced by pro-inflammatory cytokines; J. Antibiot. (Tokyo), 64 361

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Focus Biomolecules cell signaling reagent supplier, chemical structure Ansatrienin B | Cytotoxic activity | CAS 82189-04-6

Catalog#  10-1576

$345.00
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CAS:
82189-04-6
Catalog Number:
10-1576
Activity:
Cytotoxic activity
Alternate Names:
Mycotrienin II; Antibiotic T2311
Source:
Fermentation product from Streptomyces sp.
Molecular Weight:
638.87
Molecular Formula:
C36H50N2O8
Solubility:
Soluble in DMSO, DMF, Ethanol or Methanol
Physical Properties:
Pale-yellow solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO, DMF, ethanol or methanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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