Antimycin A | Mitochondrial Complex III inhibitor

Antimycin A (1397-94-0) is a mitochondrial electron transport inhibitor at complex III. Induces apoptosis in various cell lines.¹ Antimycin A may be used to generate cellular models of degenerative disorders by blocking the mitochondrial electron transport chain, disrupting energy metabolism, and elevating ROS levels.^2-4 Induces canonical PINK1-Parkin-dependent mitophagy in Parkin overexpressing cells upon cotreatment with oligomycin.⁵

References/Citations:

1. Muller et al. (2003), Architecture of the Qo site of the cytochrome bc1 complex probed by superoxide production; Biochemistry, 42 6493
2. Choi et al. (2012), Magnolol protects osteoblastic MC3T3-E1 cells against antimycin A-induced cytotoxicity through activation of mitochondrial function; Inflammation, 35 1204
3. Smith et al. (2023), Transient and Sustained Ganglion Cell Light Responses Are Differentially Modulated by Intrinsically Produced Reactive Oxygen Species Acting upon Specific Voltage-Gated Na⁺ Channel Isoforms; J. Neurosci, 43 2291
4. Barzegari et al. (2022), The protective effect of N-acetylcysteine on antimycin A-induced respiratory chain deficiency in mesenchymal stem cells; Chem. Biol. Interact., 360 109937
5. Zachari et al. (2019), Selective Autophagy of Mitochondria on a Ubiquitin-Endoplasmic-Reticulum Platform; Dev. Cell, 50 627