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AP-18 | TRPA1 blocker

CAS:
55224-94-7
Catalog Number:
10-1127
Activity:
TRPA1 blocker
Chemical Name:
4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime
Molecular Weight:
209.67
Molecular Formula:
C11H12ClNO
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Shipping Code:
RT

AP-18 (55224-94-7) is a TRPA1 channel blocker IC50=3.1-4.5 μM in various cell lines. Reduces cinnamaldehyde-induced nociception in vivo and blocks cold- and mustard oil-induced activation of mouse TRPA1 but not capsaicin-induced activation. Does not block TRPV1, V2, V3, V4 or M8 at concentrations up to 50 μM.1 Blocks TRPA1 pore dilation (IC50=10.3 μM).2 An important tool for assessing the role of TRPA1 in cell signaling and physiological processes.3-5

References”Citations:

  1. Petrus et al (2007) A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition. Mol.Pain 3 40
  2. Chen et al. (2009) Pore dilation occurs in TRPA1 but not in TRPM8 channels; Mol. Pain, 5 3
  3. Lieder et al. (2017) The Alkamide trans-Pellitorine Targets PPARγ via TRPV1 and TRPA1 to Reduce Lipid Accumulation in Developing 3T3-L1 Adipocytes; Front. Pharmacol., 8 316
  4. Chepurny et al. (2016) GPR119 Agonist AS1269574 Activates TRPA1 Cation Channels to Stimulate GLP-1 Secretion; Mol. Endocrinol., 30 614
  5. Cheah et al. (2014) Acrolein relaxes mouse isolated tracheal smooth muscle via a TRPA1-dependent mechanism; Biochem. Pharmacol., 89 148
AP-18 | TRPA1 blocker is also available in the Cellular Metabolism Library.
CAS:
55224-94-7
Catalog Number:
10-1127
Activity:
TRPA1 blocker
Chemical Name:
4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime
Molecular Weight:
209.67
Molecular Formula:
C11H12ClNO
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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