Oligomycin Complex | Mitochondrial ATPase inhibitor

CAS:
1404-19-9
Catalog Number:
10-2092
Activity:
Mitochondrial ATPase inhibitor
Source:
From Streptomyces sp.
Molecular Weight:
791.06
Molecular Formula:
C45H74O11 (for Oligomycin A)
Solubility:
Soluble in DMSO (up to 300 mg/ml) or in Ethanol (up to 200 mg/ml)
Physical Properties:
White solid
Purity:
Mixture of Oligomycin A (67.5%), B (19.4%), and C (9.8%)
97% by TLC
NMR: (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Available Options

Size :PriceQuantity 
5 mg$64.00
25 mg$260.00
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Oligomycin (1404-19-9) inhibits mitochondrial F1F0 ATP synthase.1 A useful tool for decreasing cellular ATP levels.2 Induces autophagy.3 Stimulates lysosome acidification.4 Oligomycin protects against ischemic kidney in male rats.5

References/Citations:

1) Antoniel et al. (2014), The oligomycin-sensitivity conferring protein of mitochondrial ATP synthase: emerging new roles in mitochondrial pathophysiology;  J. Mol. Sci., 15 7513
2) Ng et al. (2014), Essential role of TID1 in maintaining mitochondrial membrane potential homogeneity and mitochondrial DNA integrity;  Mol. Cell Biol., 34 1427
3) Tettamonti et al. (2006), Oligomycin A induces autophagy in the IPLB-LdFB insect cell line;  Cell Tissue Res., 326 179
4) van Dyke et al. (1993), Acidification of rat liver lysosomes:quantification and comparison with endosomes;  Am. J. Physiol., 265 C901
5) Tanaka et al. (2013), Oligomycin, an F1Fo-ATPase inhibitor, protects against ischemic acute kidney injury in male but not in female rats;  J. Pharmacol. Sci., 123 227

CAS:
1404-19-9
Catalog Number:
10-2092
Activity:
Mitochondrial ATPase inhibitor
Source:
From Streptomyces sp.
Molecular Weight:
791.06
Molecular Formula:
C45H74O11 (for Oligomycin A)
Solubility:
Soluble in DMSO (up to 300 mg/ml) or in Ethanol (up to 200 mg/ml)
Physical Properties:
White solid
Purity:
Mixture of Oligomycin A (67.5%), B (19.4%), and C (9.8%)
97% by TLC
NMR: (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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