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Product Details

Oligomycin Complex | Mitochondrial ATPase inhibitor

Oligomycin (1404-19-9) inhibits mitochondrial F1F0 ATP synthase.1 A useful tool for decreasing cellular ATP levels.2 Induces autophagy.3 Stimulates lysosome acidification.4 Oligomycin protects against ischemic kidney in male rats.5

References/Citations

1) Antoniel et al. (2014), The oligomycin-sensitivity conferring protein of mitochondrial ATP synthase: emerging new roles in mitochondrial pathophysiology;  J. Mol. Sci., 15 7513
2) Ng et al. (2014), Essential role of TID1 in maintaining mitochondrial membrane potential homogeneity and mitochondrial DNA integrity;  Mol. Cell Biol., 34 1427
3) Tettamonti et al. (2006), Oligomycin A induces autophagy in the IPLB-LdFB insect cell line;  Cell Tissue Res., 326 179
4) van Dyke et al. (1993), Acidifcation of rat liver lysosomes:quantification and comparison with endosomes;  Am. J. Physiol., 265 C901
5) Tanaka et al. (2013), Oligomycin, an F1Fo-ATPase inhibitor, protects against ischemic acute kidney injury in male but not in female rats;  J. Pharmacol. Sci., 123 227

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Catalog#  10-2092

$57.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
1404-19-9
Catalog Number:
10-2092
Activity:
Mitochondrial ATPase inhibitor
Source:
From Streptomyces sp.
Molecular Weight:
791.06
Molecular Formula:
C45H74O11 (for Oligomycin A)
Solubility:
Soluble in DMSO (up to 300 mg/ml) or in Ethanol (up to 200 mg/ml)
Physical Properties:
White solid
Purity:
Mixture of Oligomycin A (67.5%), B (19.4%), and C (9.8%)
97% by TLC
NMR: (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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