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Product Details

AR-A 014418 | GSK-3 inhibitor

AR-A 014418 (487021-52-3) is a selective glycogen synthase kinase 3 (GSK-3) inhibitor, IC50 = 104 nM. Inhibits β-amyloid-mediated neurodegeneration in hippocampal slices. Anti-inflammatory activity. Cell permeable. Active in rodent models.

References/Citations
1) Bhat et al. (2003), Structural insights and biological effects of glycongen synthase kinase 3-specific inhibitor AR-A014418; J. Biol. Chem., 278 45937
2) Ramirez et al. (2010), Inhibition of glycogen synthase kinase 3beta (GSK3β) decreases inflammatory responses in brain endothelial cells; Am. J. Pathol., 176 881

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Focus Biomolecules cell signaling reagent supplier, chemical structure AR-A 014418 | GSK-3 inhibitor | CAS 487021-52-3

Catalog#  10-1195

$65.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
487021-52-3
Catalog Number:
10-1195
Activity:
GSK-3 inhibitor
Chemical Name:
N-[(4-Methoxyphenyl)methyl]-N'-(5-nitro-2-thiazolyl)urea
Molecular Weight:
308.32
Molecular Formula:
C12H12N4O4S
Solubility:
Soluble in DMSO (up to 30 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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