my account
  Loading... Please wait...

Product Details

Ascomycin | FKBP ligand immunosuppressant

Ascomycin (11011-38-4) is an analog of FK-506 (Cat.# 10-1103). Potent immunosuppressant1. Binds to FKBP122 and inhibits calcineurin and NFAT. Ascomycin displays antiinflammatory effects in skin diseases3. Cell permeable and active in vivo.

1) Hatanaka et al. (1988), FR-900520 and FR-900523, novel immunosupressants isolated from a Streptomyces. II. Fermentation, isolation and physio-chemical and biological characteristics; J. Antibiot. (Tokyo), 41 1592
2) Petros et al. (1991), NMR studies of an FK506 analogue [U-13C]ascomycin, bound to FKBP: conformation and regions of ascomycin involved in binding; J. Med. Chem., 34 2925
3) Mollison et al. (1999), A macrolactam inhibitor of T helper type 1 and T helper type 2 cytokine biosynthesis for topical treatment of inflammatory skin diseases; J. Invest. Dermatol., 112 729

Focus Biomolecules supplier, chemical structure of Ascomycin | FKBP ligand immunosuppressant | CAS 11011-38-4

Catalog#  10-2059

Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
Request Bulk Quote
Catalog Number:
FKBP ligand; immunosuppressant
Alternate Names:
FK-520, FR-900520
Chemical Name:
Fermentation product from Streptomyces hygroscopicus
Molecular Weight:
Molecular Formula:
Soluble in DMSO (up to 50 mg/ml), or in Ethanol (up to 50 mg/ml with warming).
Physical Properties:
White solid
99% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

Connect with Focus

Click the button below to add the Ascomycin | FKBP ligand immunosuppressant to your wish list.