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Product Details
AT-101 | Bcl-2 inhibitor
AT-101 (90141-22-3) is a small molecule mimic of the BH3 domain of cellular Bcl-2 inhibitors which interferes with the function of Bcl-2-family antiapoptotic proteins. AT-101 induces apoptosis in drug-resistant multiple myeloma cell lines. Apoptosis is activated by the mitochondrial pathway. Cell permeable.
References/Citations
1) Kline et al. (2008), R-(-)-gossypol (AT-101) activates programmed cell death in multiple myeloma cells; Exp. Hematol., 36 568
2) Balakrishnan et al. (2009), AT-101 induces apoptosis in CLL B cells and overcomes stromal cell-mediated Mcl-1 induction and drug resistance; Blood, 113 149
Catalog# 10-1165
$116.00
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
CAS:
90141-22-3
Catalog Number:
10-1165
Activity:
Bcl-2 inhibitor
Alternate Names:
R(-)-Gossypol
Molecular Weight:
518.56
Molecular Formula:
C30H30O8
Solubility:
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 50 mg/ml).
Physical Properties:
Light brown solid
Purity:
>98% by TLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT
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