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Atglistatin | ATGL inhibitor

Atglistatin (1469924-27-3) is the first small molecule inhibitor of adipose triglyceride lipase (ATGL) – IC50 = 700 nM.1  It exhibits high selectivity for ATGL, is active in vitro and in vivo, and does not inhibit other key metabolic lipases.  ATGL is the rate limiting enzyme in lipolysis and is thus an excellent target to reduce fatty acid mobilization and decrease lipotoxicity in metabolic syndrome.  Inhibition of ATGL may be a useful strategy to attack the increased metabolic rate of cancerous cells.2

References/Citations

1) Mayer et al. (2013), Development of small-molecule inhibitors targeting adipose triglyceride lipase; Nat. Chem. Biol. 9 785
2) Zagani et al. (2015) Inhibition of adipose triglyceride lipase (ATGL) by the putative tumor suppressor G0S2 or a small molecule inhibitor attenuates the growth of cancer cells; Oncotarget 6 28282

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Focus Biomolecules cell signaling reagent supplier, chemical structure of Atglistatin | ATGL inhibitor | CAS 1469924-27-3

Catalog#  10-4598-0005

$60.00
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CAS:
1469924-27-3
Catalog Number:
10-4598
Activity:
ATGL inhibitor
Chemical Name:
N’-[4’-(Dimethylamino)[1,1’-biphenyl]-3-yl]-N,N,-dimethylurea
Molecular Weight:
283.37
Molecular Formula:
C17H21N3O
Solubility:
Soluble in DMSO (up to 5 mg/ml) or in Ethanol (up to 5 mg/ml with warming)
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT
CAS:
1469924-27-3
Catalog Number:
10-4598
Activity:
ATGL inhibitor
Chemical Name:
N’-[4’-(Dimethylamino)[1,1’-biphenyl]-3-yl]-N,N,-dimethylurea
Molecular Weight:
283.37
Molecular Formula:
C17H21N3O
Solubility:
Soluble in DMSO (up to 5 mg/ml) or in Ethanol (up to 5 mg/ml with warming)
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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