Autogramin-2 | Autophagy blocker / GRAMD1A inhibitor

CAS:
2375541-45-8
Catalog Number:
10-4439
Activity:
Autophagy blocker / GRAMD1A inhibitor
Chemical Name:

t-Butyl 2-[(4-propan-2-yloxybenzoyl)amino]-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-5-carboxylate

Molecular Weight:
417.53
Molecular Formula:
C21H27N3O4S
Solubility:
Soluble in DMSO (up t0 25 mg/ml) or in Ethanol (up to 25 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Available Options

Size :PriceQuantity 
5 mg$60.00
25 mg$225.00

Autogramin-2 (2375541-45-8) is an inhibitor of autophagy (autophagy induced by amino acid starvation IC50 = 270 nM; Rapamycin IC50 = 140 nM) acting via selective targeting of the cholesterol transfer protein GRAM domain-containing protein 1A (GRAMD1A).  Autogramin-2 inhibition of GRAMD1A inhibits biogenesis of the autophagosome.

References/Citations:

  1. Laraia et al. (2019), The cholesterol transfer protein GRAMD1A regulates autophagosome biogenesis; Chem. Biol., 15 710
CAS:
2375541-45-8
Catalog Number:
10-4439
Activity:
Autophagy blocker / GRAMD1A inhibitor
Chemical Name:

t-Butyl 2-[(4-propan-2-yloxybenzoyl)amino]-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-5-carboxylate

Molecular Weight:
417.53
Molecular Formula:
C21H27N3O4S
Solubility:
Soluble in DMSO (up t0 25 mg/ml) or in Ethanol (up to 25 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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