Autophagy

Autophagy is a catabolic process that enables a cell to avoid death by selectively degrading unnecessary or dysfunctional cytosolic components for recycling into energy and essential building blocks. It is employed in response to normal (for example, development) and abnormal (for example, cancer) stresses, which can be either internal (such as protein aggregates or cellular homeostasis) or external (such as nutrient limitation). More recently, autophagy has also been shown to be used as a cell death pathway [autophagic cell death (ACD)], such as in tumor suppression.

Inducers

  • MG-132 | Proteasome inhibitor
    CAS:
    133407-82-6
    Catalog Number:
    10-1309
    Activity:
    Proteasome inhibitor
    Alternate Names:
    Z-Leu-Leu-Leu-CHO
    Chemical Name:
    N-(Benzyloxycarbonyl)leucinylleucinylleucinal
    Molecular Weight:
    475.63
    Molecular Formula:
    C26H41N3O5
    Solubility:
    Soluble in DMSO (up to 45 mg/ml), in DMF (up to 45 mg/ml), or in Ethanol (up to 45 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO, DMF or ethanol may be stored at -20° for up to 1 week.
    Shipping Code:
    RT
  • SKLB-D18 | ERK1/2/5 inhibitor
    CAS:
    N/A
    Catalog Number:
    10-4092
  • PF-543 HCl | Sphingosine kinase-1 inhibitor
    CAS:
    1706522-79-3
    Catalog Number:
    10-4998
  • Oligomycin A | Mitochondrial ATPase inhibitor
    CAS:
    579-13-5
    Catalog Number:
    10-5368
    Activity:
    Mitochondrial ATPase inhibitor
    Source:
    Streptomyces sp.
    Molecular Weight:
    791.06
    Molecular Formula:
    C45H74O11
    Solubility:
    Soluble in DMSO (up to 300 mg/ml); Ethanol (up to 200 mg/ml)
    Physical Properties:
    White solid
    Purity:
    >98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • PLX4720 | Mutant B-Raf inhibitor
    CAS:
    918505-84-7
    Catalog Number:
    10-5113
    Activity:
    Mutant B-Raf inhibitor
    Chemical Names:
    N-[3-[(5-Chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide
    Molecular Weight:
    413.82
    Molecular Formula:
    C17H14ClF2N3O3S
    Solubility:
    Soluble in DMSO (30 mg/ml with warming)
    Physical Properties:
    White solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
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Inhibitors

  • Violacein | Immunostimulant
    CAS:
    548-54-9
    Catalog Number:
    10-5073
  • GNS561 | PPT1 inhibitor/STING activator
    CAS:
    1914148-73-4
    Catalog Number:
    10-4138
  • AS1842856 | FOXO1 inhibitor
    CAS:
    836620-48-5
    Catalog Number:
    10-5344
  • Vacuolin-1 | Autophagy/PIKfyve inhibitor
    CAS:
    351986-85-1
    Catalog Number:
    10-5151
  • Rotenone | Mitochondrial Complex I Inhibitor
    CAS:
    83-79-4
    Catalog Number:
    10-2277
    Activity:
    Mitochondrial Complex I Inhibitor
    Chemical Names:
    (2R,6aS,12aS)-1,2,12,12a-Tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-[1]benzopyrano[3,4-b]furo[2,3-h][1]benzopyran-6(6aH)-one
    Alternate Name:
    NSC-26285; Nicouline
    Molecular Weight:
    394.42
    Molecular Formula:
    C23H22O6
    Solubility:
    Soluble in DMSO (50 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    Room Temperature
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
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