Autophinib | Autophagy inhibitor
CAS:
1644443-47-9
Catalog Number:
10-3476
Activity:
Autophagy inhibitor
Chemical Names:
6-Chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(4-nitrophenoxy)-4-pyrimidinamine
Molecular Weight:
346.73
Molecular Formula:
C14H11ClN6O3
Solubility:
Soluble in DMSO (30 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $80.00 | ||
| 25 mg | $220.00 |
Autophinib (1644443-47-9) inhibits autophagy induced by starvation or rapamycin by inhibiting the lipid kinase VPS34 (IC50=19 nM).1 Increased autophagy and apoptosis were rescued by autophinib in Per1-overexpressing oral squamous cell carcinoma cells.2 Autophinib has quickly become an important biochemical tool for inhibition of autophagy in a variety of cellular contexts.3-5
References/Citations:
- Robke et al. (2017), Phenotypic Identification of a Novel Autophagy Inhibitor Chemotype Targeting Lipid Kinase VPS34; Angew. Chem. Int. Ed. Engl., 56 8153
- Yang et al. (2020), Loss of the clock gene Per1 promotes oral squamous cell carcinoma progression via the AKT/mTOR pathway; Cancer Sci., 111 1542
- Yang et al. (2019), Increased expression of IncRNA CASC9 promotes tumor progression by suppressing autophagy-mediated cell apoptosis via the AKT/mTOR pathway in oral squamous cell carcinoma; Cell Death Dis., 10 41
- Relic et al. (2021), TFEB phosphorylation on Serine 211 is induced by autophagy in human synovial fibroblasts and by p62/SQSTM1 overexpression in HEK293 cells; Biochem. J., 478 3145
- Li et al. (2022), The circadian clock gene ARNTL overexpression suppresses oral cancer progression by inducing apoptosis via activating autophagy; Med. Oncol., 39 244
CAS:
1644443-47-9
Catalog Number:
10-3476
Activity:
Autophagy inhibitor
Chemical Names:
6-Chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(4-nitrophenoxy)-4-pyrimidinamine
Molecular Weight:
346.73
Molecular Formula:
C14H11ClN6O3
Solubility:
Soluble in DMSO (30 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Safety Data Sheet:
N/A
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Autophinib (1644443-47-9) inhibits autophagy induced by starvation or rapamycin by inhibiting the lipid kinase VPS34 (IC50=19 nM).1 Increased autophagy and apoptosis were rescued by autophinib in Per1-overexpressing oral squamous cell carcinoma cells.2 Autophinib has quickly become an important biochemical tool for inhibition of autophagy in a variety of cellular contexts.3-5
References/Citations:
- Robke et al. (2017), Phenotypic Identification of a Novel Autophagy Inhibitor Chemotype Targeting Lipid Kinase VPS34; Angew. Chem. Int. Ed. Engl., 56 8153
- Yang et al. (2020), Loss of the clock gene Per1 promotes oral squamous cell carcinoma progression via the AKT/mTOR pathway; Cancer Sci., 111 1542
- Yang et al. (2019), Increased expression of IncRNA CASC9 promotes tumor progression by suppressing autophagy-mediated cell apoptosis via the AKT/mTOR pathway in oral squamous cell carcinoma; Cell Death Dis., 10 41
- Relic et al. (2021), TFEB phosphorylation on Serine 211 is induced by autophagy in human synovial fibroblasts and by p62/SQSTM1 overexpression in HEK293 cells; Biochem. J., 478 3145
- Li et al. (2022), The circadian clock gene ARNTL overexpression suppresses oral cancer progression by inducing apoptosis via activating autophagy; Med. Oncol., 39 244
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