my account
Login
  Loading... Please wait...

Product Details

Azoramide | UPR modulator

Azoramide (932986-18-0) is a modulator of the unfolded protein response (UPR).1  It improves endoplasmic reticulum (ER) protein folding and activates ER chaperone capacity to protect cells against ER stress. It displayed potent anti-diabetic activity in two mouse models by improving insulin sensitivity and pancreatic b cell function. Azoramide increased SERCA expression leading to enhanced calcium retention in the ER indicating calcium homeostasis as a possible mechanism for its anti-diabetic acitivty.

References/Citations

1) Fu (2015), Phenotypic assays identify azoramide as a small-molecule modulator of the unfolded protein response with antidiabetic activity; Sci. Transl. Med., 7 292ra98

swipe
Image 1

Catalog#  10-4629-0010

$50.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
Request Bulk Quote
CAS:
932986-18-0
Catalog Number:
10-4629
Activity:
UPR modulator
Chemical Name:
N-[2-[2-(4-Chlorophenyl)-4-thiazolyl]ethyl]butanamide
Molecular Weight:
308.83
Molecular Formula:
C15H17ClN2OS
Solubility:
Soluble in DMSO (up to at least 25 mg/ml) or in ethanol (up to at least 25 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

Connect with Focus

Click the button below to add the Azoramide | UPR modulator to your wish list.