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Product Details

b-AP15 | DUB inhibitor

b-AP15 (1009817-63-3) abrogates the deubiquitinating activity of the 19S regulatory particle by inhibiting ubiquitin C-terminal hydrolase 5 (UCHL5) and ubiquitin-specific peptidase 14 (USP14) resulting in accumulation of polyubiquitin in cells. b-AP15 induces tumor cell apoptosis and tumor progression in four different solid tumor models in vivo.

References/Citations
1) D'Arcy et al. (2011), Inhibition of proteasome deubiquitinating activity as a new cancer therapy; Nature Medicine, 17 1636

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b-AP15 | 1009817-63-3 | Structure | Supplier

Catalog#  10-1340

$60.00
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Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
1009817-63-3
Catalog Number:
10-1340
Activity:
DUB inhibitor
Alternate Names:
NSC-687852
Chemical Name:
3,5-bis[(4-Nitrophenyl)methylidene]-1-prop-2-enoylpiperidin-4-one
Molecular Weight:
419.4
Molecular Formula:
C22H17N3O6
Solubility:
Soluble in DMSO (up to 35 mg/ml).
Physical Properties:
Pale yellow solid
Purity:
>98% by HPLC
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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