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Product Details

BADGE | PPAR gamma antagonist

BADGE (1675-54-3) is a PPARγ antagonist with μM affinity in 3T3-L1 and 3T3-F442A preadipocyte cells. Selective over PPARδ and PPARα. Antagonizes the ability of rosiglitazone to stimulate transcriptional activity of PPARγ and abolishes its anti-inflammatory effects in a mouse model1. Induces apoptosis via PPARγ-independent mechanisms2. Induces adipogenesis in human and mouse mesenchymal stromal stem cells and in mouse 3T3-L1 preadipocytes at low nM concentrations via a PPARγ independent mechanism3. Increases osteoblastogenesis and bone mass in a mouse model4. Active in vivo.

References/Citations

1) Cuzzocrea et al. (2004), Rosiglitazone , a ligand of the peroxisome proliferator-activated receptor-gamma, reduces acute inflammation; Eur. J. Pharmacol., 483 79
2) Fehlberg et al. (2003), Bisphenol A diglycidyl ether-induced apoptosis involves Bax/Bid-dependent mitochondrial release of apoptosis-inducing factor (AIF), cytochrome c and Smac/DIABLO; Br. J. Pharmacol., 139 495
3) Chamorro-Garcia et al. (2012), Bisphenol A diglycidyl ether induces adipogenic differentiation of multipotent stromal stem cells through a peroxisome proliferator-activated receptor gamma-independent mechanism; Environ. Health Perspect., 120 984
4) Duque et al. (2013), Pharmacological inhibition of PPARgamma increases osteoblastogenesis and bone mass in male C57BL/6 mice; J. Bone Miner. Res., 28 639

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Focus Biomolecules cell signaling reagent supplier, chemical structure of BADGE | PPAR gamma antagonist | CAS 1675-54-3

Catalog#  10-2618-0010

$30.00
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CAS:
1675-54-3
Catalog Number:
10-2618
Activity:
PPARγ antagonist
Chemical Name:
2,3-Bis[4-(2,3-epoxypropoxy)phenyl]propane
Alternate Names:
Bisphenol A diglycidyl ether
Molecular Weight:
340.41
Molecular Formula:
C21H24O4
Solubility:
Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 15 mg/ml)
Physical Properties:
White low melting point solid
Purity:
95% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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