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Product Details

Baricitinib | JAK 1/2 inhibitor

Baricitinib (1187594-09-7), approved by the FDA for two inflammatory disorders, rheumatoid arthritis and alopecia areata, selectively inhibits Janus kinase 1 (IC50 = 5.9 nM) and 2 (5.7 nM), over 3 (0.56 µM).1 It thereby blocks JAK/STAT signaling, reducing cytokine release and suppressing the innate and adaptive immune systems.1,2 Was recently shown to significantly improve COVID-19 symptoms in a preliminary human trial, presumably through suppression of the cytokine release syndrome (“cytokine storm”) induced by SARS-CoV-2 infection.3

References/Citations
1) Fridman et al. (2010), Selective Inhibition of JAK1 and JAK2 Is Efficacious in Rodent Models of Arthritis: Preclinical Characterization of INCB028050; J. Immunol. Biol., 184 5298
2) Kubo et al. (2018), Janus Kinase Inhibitor Baricitinib Modulates Human Innate and Adaptive Immune System; Front. Immunol., 9 1510
3) Cantini et al. (2020), Baricitinib Therapy in COVID-19: A Pilot Study on Safety and Clinical Impact; J. Infect.., April 23, DOI: 10.1016/j.jinf.2020.04.017

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Catalog#  10-3893-0005

$50.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
1187594-09-7
Catalog Number:
10-3893
Activity:
JAK 1/2 inhibitor
Chemical Name:
1-(Ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-3-azetidine-acetonitrile
Alternate Name:
INCB028050; LY3009104
Molecular Weight:
371.42
Molecular Formula:
C16H17N7O2S
Solubility:
Soluble in DMSO (up to 30 mg/ml) or in DMF (up to 50 mg/ml).
Physical Properties:
White or off-white solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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