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Product Details

BAY 11-7082 | IKK inhibitor

BAY 11-7082 (19542-67-7) selectively inhibits TNFα-induced phosphorylation of IκB-α leading to decreased nuclear NF-κB and decreased adhesion molecule expression without affecting constitutive IκB-α phosphorylation.1 The effects on adhesion molecule expression were found to be irreversible.

References/Citations
1) Pierce et al. (1997) Novel inhibitor of cytokine-induced IκBα phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo: J. Biol. Chem. 272 21096

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Focus Biomolecules cell signaling reagent supplier, chemical structure of BAY 11-7082 | IKK inhibitor | CAS 19542-67-7

Catalog#  10-1296

$70.00
Quantity
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CAS:
19542-67-7
Catalog Number:
10-1296
Activity:
IKK inhibitor
Chemical Name:
(E)-3-(4-Methylphenylsulfonyl)-2-propenenitrile
Molecular Weight:
207.27
Molecular Formula:
C10H9NO2S
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 15 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by TLC
Storage Temperature:
RT
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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