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Product Details

BAY 11-7082 | IKK inhibitor

BAY 11-7082 (19542-67-7) inhibits cytokine-induced IκB-α phosphorylation via inhibition of IκB Kinase which results in inhibition of NFκB 1. Inhibits anchorage-independent growth of mammary epithelial cells induced with 4-hydroxyestradiol via inhibition of NFκB activation2. Inhibits IFNα production and blocks nuclear translocation of IRF7 in plasmacytoid dendritic cells3.  Facilitates wound healing by inhibiting TNFα-induced MMP expression4. A useful tool for probing the involvement of NFκB in physiological and pathophysiological processes5.  Cell permeable.

References/Citations
1) Pierce et al. (1997) Novel inhibitor of cytokine-induced IkBα phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo; J. Biol. Chem., 272 21096
2) Park et al. (2009) 4-hydroxyestradiol induces anchorage-independent growth of human mammary epithelial cells via activation of IkappaB kinase: potential role of reactive oxygen species; Cancer Res., 69 2416
3) Miyamoto et al. (2010) Inhibitor of IkappaB kinase activity, BAY 11-7082, interferes with interferon regulatory factor 7 nuclear translocation and type I interferon production by plasmacytoid dendritic cells; Arthritis Res. Ther., 12 R87
4) Xu et al. (2019) Bay 11-7082 facilitates wound healing by antagonizing mechanical injury – and TNF-α-induced expression of MMPs in posterior cruciate ligament; Connect. Tissue Res. 60 311
5) Kim et al. (2018) TNF-α induces human neural progenitor cell survival after oxygen-glucose deprivation by activating the NFκB pathway; Exp. Mol. Med., 50 14

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Focus Biomolecules cell signaling reagent supplier, chemical structure of BAY 11-7082 | IKK inhibitor | CAS 19542-67-7

Catalog#  10-1296

$60.00
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Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
19542-67-7
Catalog Number:
10-1296
Activity:
IKK inhibitor
Chemical Name:
(E)-3-(4-Methylphenylsulfonyl)-2-propenenitrile
Molecular Weight:
207.27
Molecular Formula:
C10H9NO2S
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 15 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by TLC
Storage Temperature:
RT
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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