BC-11-38 | PDE-11 inhibitor
NMR (Conforms)
Available Options
| size : | Price | Quantity | |
|---|---|---|---|
| 10 mg | $50.00 | ||
| 50 mg | $200.00 |
BC-11-38 (686770-80-9) is a potent and selective inhibitor of phosphodiesterase PDE11 (IC50=0.28 µM).1 IC50s for PDE1-10 are greater than 100 µM. Restores the ability of p54nrb / NONOKD cells to generate cAMP in response to ACTH stimulation and the production of cortisol and DHEA in response to cAMP signaling.2
References/Citations:
1) Ceyhan et al. (2012), Identification of biologically active PDE11-selective inhibitors using a yeast-based high-throughput screen; Chem. Biol., 19 155
2) Lu and Sewer (2015), p54nrb/NONO regulates cyclic AMP-dependent glucocorticoid production by modulating phosphodiesterase mRNA splicing and degradation; Mol. Cell. Biol. 35 1223
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
BC-11-38 (686770-80-9) is a potent and selective inhibitor of phosphodiesterase PDE11 (IC50=0.28 µM).1 IC50s for PDE1-10 are greater than 100 µM. Restores the ability of p54nrb / NONOKD cells to generate cAMP in response to ACTH stimulation and the production of cortisol and DHEA in response to cAMP signaling.2
References/Citations:
1) Ceyhan et al. (2012), Identification of biologically active PDE11-selective inhibitors using a yeast-based high-throughput screen; Chem. Biol., 19 155
2) Lu and Sewer (2015), p54nrb/NONO regulates cyclic AMP-dependent glucocorticoid production by modulating phosphodiesterase mRNA splicing and degradation; Mol. Cell. Biol. 35 1223
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