Cyclic Nucleotides

Cyclic Nucleotides, such as cAMP and cGMP, play pivotal roles in metabolism, memory, vision, as well as fundamental processes like cell adhesion and division. They act as second messengers that transmit signals from the plasma membrane by binding to proteins such as certain kinases, ion channels, or transcription factors, which activate specific signaling pathways.

Adenylate Cyclase Activators

  • Forskolin | Adenylate cyclase activator
    CAS:
    66575-29-9
    Catalog Number:
    10-2073
    Activity:
    Adenylate cyclase activator
    Chemical Name:
    7β-Acetoxy-8,13-epoxy-1α,6β,9α-trihydroxylabd-14-en-11-one
    Molecular Weight:
    410.51
    Molecular Formula:
    C22H34O7
    Solubility:
    Soluble in DMSO (up to 10 mg/ml).
    Physical Properties:
    White solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 4 months.
    Shipping Code:
    RT
View All Adenylate Cyclase Activators Products

cAMP

  • RU.521 | cGAS Inhibitor
    CAS:
    2262452-06-0
    Catalog Number:
    10-4140
    Activity:
    cGAS Inhibitor
    Chemical Name:

    3-[1-(6,7-Dichloro-1H-benzimidazol-2-yl)-5-hydroxy-3-methylpyrazol-4-yl]-3H-isobenzofuran-1-one

    Molecular Weight:
    415.23
    Molecular Formula:
    C19H12Cl2N4O3
    Solubility:
    Soluble in DMSO (>25 mg/ml)
    Physical Properties:
    Off-white to pale pink solid
    Purity:
    >98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • Dibutyryl cAMP | Cell permeable cAMP
    CAS:
    16980-89-5
    Catalog Number:
    10-2627
    Activity:
    Cell permeable cAMP
    Chemical Name:
    N6,O2′-Dibutyryl adenosine 3′,5′-cyclic monophosphate sodium salt
    Alternate Name:
    Bucladesine Na
    Molecular Weight:
    491.37
    Molecular Formula:
    C18H23N5O8P ∙ Na
    Solubility:
    Soluble in DMSO (up to 50 mg/ml) or in water (up to 50 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
  • ST034307 | Adenylate cyclase 1 inhibitor/analgesic activity
    CAS:
    133406-29-8
    Catalog Number:
    10-1620
    Activity:
    Adenylate cyclase 1 inhibitor/analgesic activity
    Chemical Name:
    6-Chloro-2-(trichloromethyl)-4H-1-benzopyran-4-one
    Molecular Weight:
    297.95
    Molecular Formula:
    C10H4Cl4O2
    Solubility:
    Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 6 mg/ml)
    Physical Properties:
    Yellow solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • 8-pCPT-2-O-Me-cAMP-AM | Epac activator
    CAS:
    1152197-23-3
    Catalog Number:
    10-2736
    Activity:
    Epac activator
    Chemical Name:
    8-(4-Chlorophenylthio)-2′-O-methyladenosine-3′,5′-cyclic monophosphate, acetoxymethyl ester
    Molecular Weight:
    557.91
    Molecular Formula:
    C20H21ClN5O8PS
    Solubility:
    Soluble in DMSO (up to 50 mg/ml).
    Physical Properties:
    solid
    Purity:
    97% by HPLC
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
View All cAMP Products

cGMP

  • Decoyinine | Inhibitor of GMP synthase
    CAS:
    2004-04-8
    Catalog Number:
    10-5149
  • RU.521 | cGAS Inhibitor
    CAS:
    2262452-06-0
    Catalog Number:
    10-4140
    Activity:
    cGAS Inhibitor
    Chemical Name:

    3-[1-(6,7-Dichloro-1H-benzimidazol-2-yl)-5-hydroxy-3-methylpyrazol-4-yl]-3H-isobenzofuran-1-one

    Molecular Weight:
    415.23
    Molecular Formula:
    C19H12Cl2N4O3
    Solubility:
    Soluble in DMSO (>25 mg/ml)
    Physical Properties:
    Off-white to pale pink solid
    Purity:
    >98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • YC-1 | Soluble guanylyl cyclase activator
    CAS:
    170632-47-0
    Catalog Number:
    10-1581
    Activity:
    Soluble guanylyl cyclase activator
    Chemical Name:
    3-(5′-Hydroxymethyl-2′-furyl)-1-benzylindazole
    Alternate Name:
    Lificiguat
    Molecular Weight:
    304.34
    Molecular Formula:
    C19H16N2O2
    Solubility:
    Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 15 mg/ml).
    Physical Properties:
    Pink solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • ODQ | Soluble guanylyl cyclase inhibitor
    CAS:
    41443-28-1
    Catalog Number:
    10-1211
    Activity:
    Soluble guanylyl cyclase inhibitor
    Chemical Name:
    1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one
    Molecular Weight:
    187.5
    Molecular Formula:
    C9H5N3O2
    Solubility:
    Soluble in DMSO (up to 40 mg/ml).
    Physical Properties:
    Pale yellow solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
View All cGMP Products

Guanylate Cyclase Activators

  • YC-1 | Soluble guanylyl cyclase activator
    CAS:
    170632-47-0
    Catalog Number:
    10-1581
    Activity:
    Soluble guanylyl cyclase activator
    Chemical Name:
    3-(5′-Hydroxymethyl-2′-furyl)-1-benzylindazole
    Alternate Name:
    Lificiguat
    Molecular Weight:
    304.34
    Molecular Formula:
    C19H16N2O2
    Solubility:
    Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 15 mg/ml).
    Physical Properties:
    Pink solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
View All Guanylate Cyclase Activators Products

Inhibitors

  • Decoyinine | Inhibitor of GMP synthase
    CAS:
    2004-04-8
    Catalog Number:
    10-5149
  • ODQ | Soluble guanylyl cyclase inhibitor
    CAS:
    41443-28-1
    Catalog Number:
    10-1211
    Activity:
    Soluble guanylyl cyclase inhibitor
    Chemical Name:
    1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one
    Molecular Weight:
    187.5
    Molecular Formula:
    C9H5N3O2
    Solubility:
    Soluble in DMSO (up to 40 mg/ml).
    Physical Properties:
    Pale yellow solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • NKY-80 | Adenylate cyclase inhibitor
    CAS:
    299442-43-6
    Catalog Number:
    10-1482
    Activity:
    Adenylate cyclase inhibitor
    Chemical Name:
    2-Amino-7-(2-furanyl)-7,8-dihydro-5(6H)-quinazolinone
    Molecular Weight:
    229.24
    Molecular Formula:
    C12H11N3O2
    Solubility:
    Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 5 mg/ml with warming).
    Physical Properties:
    Gold-colored solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C (des.)
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
View All Inhibitors Products

Other Cyclic Nucleotides

  • EPAC 5376753 | EPAC inhibitor
    Catalog Number:
    10-1564
    Activity:
    EPAC inhibitor
    Chemical Name:
    5-((5-(2,4-Dichlorophenyl)furan-2-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
    Molecular Weight:
    367.21
    Molecular Formula:
    C15H8Cl2N2O3S
    Solubility:
    Soluble in DMSO (up to 15 mg/ml) or in DMF (up to 10 mg/ml)
    Physical Properties:
    Orange-red solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Mycophenolate mofetil | Immunomodulator
    CAS:
    128794-94-5
    Catalog Number:
    10-2086
    Activity:
    Immunomodulator
    Chemical Name:
    6-(1,3-Dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoic acid 2-(4-morpholinyl)ethyl ester
    Molecular Weight:
    433.51
    Molecular Formula:
    C23H31NO7
    Solubility:
    Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 4 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
View All Other Cyclic Nucleotides Products

Phosphodiesterases

  • ITI-214 | Selective PDE1 inhibitor
    CAS:
    1642303-38-5
    Catalog Number:
    10-4362
  • D159687 | Selective PDE4D inhibitor
    CAS:
    1155877-97-6
    Catalog Number:
    10-4367
  • PF-04447943 | Selective PDE9A inhibitor
    CAS:
    1082744-20-4
    Catalog Number:
    10-4365
  • TAK-063 | Selective PDE10A inhibitor
    CAS:
    1238697-26-1
    Catalog Number:
    10-4364
  • IBMX | PDE inhibitor
    CAS:
    28822-58-4
    Catalog Number:
    10-1008
    Activity:
    PDE inhibitor
    Alternate Names:
    3-Isobutyl-1-methylxanthine
    Chemical Name:
    3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione
    Molecular Weight:
    222.25
    Molecular Formula:
    C10H14N4O2
    Solubility:
    Soluble in DMSO (up to 15 mg/ml) or in Ethanol (up to 10 mg/ml).
    Physical Properties:
    White solid
    Purity:
    99% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All Phosphodiesterases Products