BE2012 | REV-ERBα/ß antagonist

BE2012 chemical structure

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BE2012 (667889-47-6) is an antagonist of REV-ERBα (EC50 = 285 nM) and REV-ERBß (EC50 = 346 nM).  Highly selective with no activity against a panel of nine closely related nuclear receptors and other receptors.  BE2012 induced myogenesis in a mouse model of acute muscle injury resulting in muscle regeneration and repair via induction of transcription factors Myf5 and Myod.

References/Citations:

  1. Maram et al. (2026) Discovery of BE2012, a First-in-Class REV-ERBα/ß Antagonist with Favorable Selectivity and Pharmacokinetics, and In Vivo Efficacy in Inducing Key Myogenic Factors for Muscle Repair upon Acute Muscle Injury; J.  Med. Chem. 69 439
667889-47-6, BE2012, BE2012 supplier, REV ERB antagonist, REV ERBß antagonist, REV ERBα antagonist, REV ERBα/ß antagonist

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Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

BE2012 (667889-47-6) is an antagonist of REV-ERBα (EC50 = 285 nM) and REV-ERBß (EC50 = 346 nM).  Highly selective with no activity against a panel of nine closely related nuclear receptors and other receptors.  BE2012 induced myogenesis in a mouse model of acute muscle injury resulting in muscle regeneration and repair via induction of transcription factors Myf5 and Myod.

References/Citations:

  1. Maram et al. (2026) Discovery of BE2012, a First-in-Class REV-ERBα/ß Antagonist with Favorable Selectivity and Pharmacokinetics, and In Vivo Efficacy in Inducing Key Myogenic Factors for Muscle Repair upon Acute Muscle Injury; J.  Med. Chem. 69 439