Benztropine mesylate | Induces remyelination of neurons
NMR (Conforms)
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|---|---|---|---|
| 1 gram | $38.00 |
Benztropine mesylate (132-17-2) is a centrally acting M1 muscarinic acetylcholine receptor antagonist (Ki=0.59 nM, rat).1 Also inhibits the dopamine transporter (Ki=160 nM).2 Benztropine mesylate enhances remyelination and significantly decreases clinical severity in the experimental autoimmune encephalomyelitis model of relapsing-remitting multiple sclerosis alone or in combination with immunosuppressive agents.3 Inhibits hepatitis C virus infection.4
References/Citations:
1) Zhang et al. (2001), Synthesis and biological evaluation of tropane-like 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR 12909) analogues; J. Med. Chem., 44 3937
2) Schmitt et al. (2008), Interaction of cocaine-, benztropine-, and GBR12909-like compounds with wild-type and mutant human dopamine transporters: molecular features that differentially determine antagonist binding properties; J. Neurochem., 107 928
3) Deshmukh et al. (2013), A regenerative approach to the treatment of multiple sclerosis; Nature, 502 327
4) Mingorance et al. (2014), Selective inhibition of hepatitis C virus infection by hydroxyzine and benztropine: Agents Chemother., 58 3451
NMR (Conforms)
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Product Data Sheet:
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Benztropine mesylate (132-17-2) is a centrally acting M1 muscarinic acetylcholine receptor antagonist (Ki=0.59 nM, rat).1 Also inhibits the dopamine transporter (Ki=160 nM).2 Benztropine mesylate enhances remyelination and significantly decreases clinical severity in the experimental autoimmune encephalomyelitis model of relapsing-remitting multiple sclerosis alone or in combination with immunosuppressive agents.3 Inhibits hepatitis C virus infection.4
References/Citations:
1) Zhang et al. (2001), Synthesis and biological evaluation of tropane-like 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR 12909) analogues; J. Med. Chem., 44 3937
2) Schmitt et al. (2008), Interaction of cocaine-, benztropine-, and GBR12909-like compounds with wild-type and mutant human dopamine transporters: molecular features that differentially determine antagonist binding properties; J. Neurochem., 107 928
3) Deshmukh et al. (2013), A regenerative approach to the treatment of multiple sclerosis; Nature, 502 327
4) Mingorance et al. (2014), Selective inhibition of hepatitis C virus infection by hydroxyzine and benztropine: Agents Chemother., 58 3451
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