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Betulinic Acid | Induces mitochondrial permeability pore opening

Betulinic acid (472-15-1) is a natural Lupane triterpenoid from white birch tree (Betula pubescens). Induces apoptosis in a variety of cell lines.1 Induces mitochondrial permeability transition pore opening.2  Acts as a chemosensitizer for anticancer drug treatment in chemoresistant colon cancer cell lines.3 Cell permeable.

References/Citations

1) Ehrhardt et al. (2004) Betulinic acid-induced apoptosis in leukemia cells; Leukemia, 18 1406
2) Mullauer et al. (2009) Betulinic acid induces cytochrome c release and apoptosis in Bax/Bak-independent, permeability transition pore dependent fashion.; Apoptosis, 14 191
3) Jung et al. (2007) Effect of betulinic acid on anticancer drug-resistant colon cancer cells; Basic Clin. Pharmacol. Toxicol., 101 277

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Catalog#  10-2278-0010

$30.00
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CAS:
472-15-1
Catalog Number:
10-2278
Activity:
Induces mitochondrial permeability pore opening
Chemical Name:
3§-Hydroxy-20(29)-lupaene-28-oic acid
Molecular Weight:
456.72
Molecular Formula:
C30H48O3
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
Physical Properties:
White or off-white solid
Purity:
98% by TLC
NMR (Conforrms)
Storage Temperature:
-20°
Stability:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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