BI01455810 | NaCT inhibitor

CAS:
 2227549-51-9
Catalog Number:
 10-4909

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BI01455810 (2227549-51-9) is a potent (IC50s = 285 nM HEK293; 184 nM HepG2) and selective inhibitor of the human (but not mouse) citrate transporter NaCT (SLC13A5).1 It inhibited citrate-induced and NaCT-mediated increases in the level of cellular oxygen consumption rate.

References/Citations:

  1. Quigley al. (2026), Discovery and Characterization of a Nonacidic Small-Molecules Inhibitor of the Sodium-Coupled Dicarboxylate Transporter NaCT; J. Med. Chem., 69 10046
2227549-51-9, BI-01455810, BI01455810, BI01455810 supplier, NaCT inhibitor
CAS:
2227549-51-9
Catalog Number:
10-4909
Activity:
NaCT inhibitor
Chemical Names:
1-(3-Bromo-5-methylbenzenesulfonyl)piperidine-4-carboxylic acid (pyridine-2-ylmethyl)amide
Alternate Name:
1-[3-Bromo-5-methylphenyl)sulfonyl]-N-(2-pyridinylmethyl)-4-piperidinecarboxamide
Molecular Weight:
452.37
Molecular Formula:

C19H22BrN3O3S

Solubility:
Soluble in DMSO (70 mg/ml)
Physical Properties:
Off-white solid
Purity:

>98% HPLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

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Product Data Sheet:

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BI01455810 (2227549-51-9) is a potent (IC50s = 285 nM HEK293; 184 nM HepG2) and selective inhibitor of the human (but not mouse) citrate transporter NaCT (SLC13A5).1 It inhibited citrate-induced and NaCT-mediated increases in the level of cellular oxygen consumption rate.

References/Citations:

  1. Quigley al. (2026), Discovery and Characterization of a Nonacidic Small-Molecules Inhibitor of the Sodium-Coupled Dicarboxylate Transporter NaCT; J. Med. Chem., 69 10046

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