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Bleomycin sulfate | Induces double strand DNA breaks

Bleomycin sulfate (9041-93-4) coordinates with metals producing reactive oxygen species which causes oxidative damage to DNA1 and RNA2. Induces double-strand DNA damage.3 Commonly used to induce lung fibrosis in animal disease models.4,5 Anticancer agent in clinical use.6

References/Citations

1) Petering et al. (1990), The role of redox-active metals in the mechanism of action of bleomycin; Chem. Biol. Interact., 73 133
2) Huttenhofer et al. (1992), Cleavage of tRNA by Fe(II)-bleomycin; J. Biol. Chem., 267 24471
3) Lee et al. (2017) ASF1a Promotes Non-homologous End Joining Repair by facilitating Phosphorylation of MDC1 by ATM at Double-Strand Breaks; Mol. Cell 68 61
4) Xie et al. (2016), Upregulation of RGS2: a new mechanism for pirfenidone amelioration of pulmonary fibrosis; Respir. Res., 17 103
5) Inomata et al. (2014) Pirfenidone inhibits fibrocyte accumulation in the lungs in bleomycin-induced murine pulmonary fibrosis; Respir. Res., 15 16
6) Tanaka et al. (2008) Increased glutathione level is not involved in enhanced bleomycin sensitivity in cisplatin-resistant 2780CP cells; Anticancer Res., 28 2663

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Focus Biomolecules supplier, chemical structure of Bleomycin sulfate | Induces double strand DNA breaks | CAS 9041-93-4

Catalog#  10-2623-0005

$90.00
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CAS:
9041-93-4
Catalog Number:
10-2623
Activity:
Fibrosis-inducing agent
Source:
From Streptomyces verticillus
Molecular Weight:
1512.62
Molecular Formula:
C55H85N17O25S4
Solubility:
Soluble in Water (up to 20 mg/ml)
Physical Properties:
White or off-white solid
Purity:
Contains a mixture of A2 (~70%) and B2 (~30%) forms
95% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year from the date of purchase. Solutions in distilled water may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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