my account
Login
  Loading... Please wait...

Product Details

BML-277 | CHK2 inhibitor

BML-277 (516480-79-8) is a potent selective inhibitor of Chk2 (IC50 = 15 nM). BML-277 has been screened against a panel of 35 kinases, and shows less that 25% inhibition of any other kinase at 10 μM, demonstrating the selectivity1. Also displays radioprotective activity, preventing apoptosis in human T-cells that were subjected to ionizing radiation (EC50 = 3.0-7.6 μM).

References/Citations
1) Arienti et al. (2005), Checkpoint kinases inhibitors: SAR and radioprotective properties of a series of 2-arylbenzimidazoles; J. Med. Chem., 48 1873
2) Pereg et al. (2006), Differential roles of ATM- and Chk2-mediated phosphorylations of Hdmx in response to DNA damage; Mol. Cell. Biol., 26 6819

swipe
BML-277 | 516480-79-8 | Structure | Supplier

Catalog#  10-1024

$90.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
Request Bulk Quote
CAS:
516480-79-8
Catalog Number:
10-1024
Activity:
CHK2 inhibitor
Chemical Name:
2-(4-(4-Chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide
Molecular Weight:
363.81
Molecular Formula:
C20H14ClN3O2
Solubility:
Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 20 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR conforms
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

Connect with Focus

Click the button below to add the BML-277 | CHK2 inhibitor to your wish list.