BML-288 (851-55-3) is a potent and selective inhibitor of phosphodiesterase PDE2, IC50 = 40 nM. More potent than EHNA, another commonly used PDE2 inhibitor. Displays no effect on a panel of over 80 receptors, ion channels and enzymes.1 Cell permeable.
1) Chambers et al. (2006), A new chemical tool for exploring the physiological function of the PDE2 isozyme; Bioorg. Med. Chem. Lett., 16 307