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Product Details

BML283 | PKM2 activator

BML283 (562867-96-3) is a selective activator of the Tumor Specific M2 Isoform of Pyruvate Kinase (PKM2) - AC50 = 111nM.1 PKM2 activity is downregulated in most cancer cells leading to a decrease in catabolic metabolism and an increase in anabolic metabolism.2,3 BML283 is an important tool for studying the effects of PKM2 and cancer metabolism.

References/Citations
1) Boxer et al., (2010), Evaluation of N,N'-Diarylsulfonamides as Activators of theTumor Specific M2 Isoform of Pyruvate Kinase; J. Med. Chem., 53 1048
2) Israelsen et al. (2013), PKM2 Isoform-Specific Deletion Reveals A Differential Requirement for Pyruvate Kinase in Tumor Cells; Cell 155 397
3) Wong et al. (2015), PKM2 contributes to cancer metabolism; Cancer Lett. 356 184

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Catalog#  10-4561

$45.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
562867-96-3
Catalog Number:
10-4561
Activity:
PKM2 activator
Alternate Names:
ML083
Chemical Name:
1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-ylsulfonyl)-4-(4-methoxyphenylsulfonyl)piperazine
Molecular Weight:
454.51
Molecular Formula:
C19H22N2O7S2
Solubility:
Soluble in DMSO (up to 10 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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