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Product Details

BMS-202 | PD-1/PD-L1 inhibitor

BMS-202 (1675203-84-5) inhibits (IC50 = 18nM) formation of the PD-1/PD-L1 complex via binding to PD-L1 and inducing dimerization.1,2

References/Citations

1) Zak et al. (2016), Structural basis for small molecule targeting of the programmed death ligand 1 (PD-L1); Oncotarget 7 30323
2) Guzik et al. (2017), Small-molecule inhibitors of the programmed cell death -1/programmed cell death -ligand 1(PD-1/PD-L1) interaction via transiently induced protein states and dimerization of PD-L1; J. Med. Chem. 60 5857

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Catalog#  10-4900-0005

$99.00
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CAS:
1675203-84-5
Catalog Number:
10-4900
Activity:
PD-1/PD-L1 inhibitor
Chemical Name:
N-[2-[[2-Methoxy-6-[(2-methyl-3-phenylphenyl)methoxy]pyridine-3-yl]methylamino]ethyl]acetamide
Alternate Name:
PD-1/PD-L1 Inhibitor 2
Molecular Weight:
419.53
Molecular Formula:
C25H29N3O3
Solubility:
Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to at least 25 mg/ml)
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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