BMS-833923 | Smoothened antagonist

CAS:
 1059734-66-5
Catalog Number:
 10-3049
BMS833923 chemical structure

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BMS-833923 (1059734-66-5) is a smoothened (SMO) antagonist.  It decreased cell proliferation and induced apoptosis (EC50=10 mM) via the intrinsic pathway in esophageal adenocarcinoma cell lines.1 Ameloblastoma cells with an activating SMO-L412F mutation were insensitive to vismodegib (another SMO antagonist) but BMS-833923 significantly reduced downstream Hedgehog signaling and tumor cell viability.2 In developmental studies BMS-833923 has been characterized as a uniquely effective SMO inhibitor when it was used to show that  Sonic hedgehog is functionally dedicated to ray branching during fin regeneration in zebrafish.3 Orally active.

References/Citations:

  1. Zaidi et al. (2013), Smoothened inhibition leads to decreased proliferation and induces apoptosis in esophageal adenocarcinoma cells; Cancer Invest., 31 480
  2. Nguyen et al. (2022), New Ameloblastoma Cell Lines Enable Preclinical Study of Targeted Therapies; J. Dent. Res., 101 1517
  3. Armstrong et al. (2017), Shh promotes direct interactions between epidermal cells and osteoblast progenitors to shape regenerated zebrafish bone; Development, 144 1165
1059734-66-5, BMS-833923, BMS-833923 supplier, BMS833923, BMS833923 supplier, SMO antagonist, Smoothened antagonist
CAS:
1059734-66-5
Catalog Number:
10-3049
Activity:
Smoothened antagonist
Chemical Names:
N-(2-Methyl-5-((methylamino)methyl)phenyl)-4-((4-phenylquinazolin-2-yl)amino)benzamide
Alternate Name:
XL-139
Molecular Weight:
473.58
Molecular Formula:

C30H27N5O

Solubility:
Soluble in DMSO (25 mg/ml)
Physical Properties:
Yellow solid
Purity:

>98% HPLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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BMS-833923 (1059734-66-5) is a smoothened (SMO) antagonist.  It decreased cell proliferation and induced apoptosis (EC50=10 mM) via the intrinsic pathway in esophageal adenocarcinoma cell lines.1 Ameloblastoma cells with an activating SMO-L412F mutation were insensitive to vismodegib (another SMO antagonist) but BMS-833923 significantly reduced downstream Hedgehog signaling and tumor cell viability.2 In developmental studies BMS-833923 has been characterized as a uniquely effective SMO inhibitor when it was used to show that  Sonic hedgehog is functionally dedicated to ray branching during fin regeneration in zebrafish.3 Orally active.

References/Citations:

  1. Zaidi et al. (2013), Smoothened inhibition leads to decreased proliferation and induces apoptosis in esophageal adenocarcinoma cells; Cancer Invest., 31 480
  2. Nguyen et al. (2022), New Ameloblastoma Cell Lines Enable Preclinical Study of Targeted Therapies; J. Dent. Res., 101 1517
  3. Armstrong et al. (2017), Shh promotes direct interactions between epidermal cells and osteoblast progenitors to shape regenerated zebrafish bone; Development, 144 1165

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