BMS-833923 | Smoothened antagonist

BMS833923 chemical structure

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BMS-833923 (1059734-66-5) is a smoothened (SMO) antagonist.  It decreased cell proliferation and induced apoptosis (EC50=10 mM) via the intrinsic pathway in esophageal adenocarcinoma cell lines.1 Ameloblastoma cells with an activating SMO-L412F mutation were insensitive to vismodegib (another SMO antagonist) but BMS-833923 significantly reduced downstream Hedgehog signaling and tumor cell viability.2 In developmental studies BMS-833923 has been characterized as a uniquely effective SMO inhibitor when it was used to show that  Sonic hedgehog is functionally dedicated to ray branching during fin regeneration in zebrafish.3 Orally active.

References/Citations:

  1. Zaidi et al. (2013), Smoothened inhibition leads to decreased proliferation and induces apoptosis in esophageal adenocarcinoma cells; Cancer Invest., 31 480
  2. Nguyen et al. (2022), New Ameloblastoma Cell Lines Enable Preclinical Study of Targeted Therapies; J. Dent. Res., 101 1517
  3. Armstrong et al. (2017), Shh promotes direct interactions between epidermal cells and osteoblast progenitors to shape regenerated zebrafish bone; Development, 144 1165
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Alternate Name:
XL-139

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Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

BMS-833923 (1059734-66-5) is a smoothened (SMO) antagonist.  It decreased cell proliferation and induced apoptosis (EC50=10 mM) via the intrinsic pathway in esophageal adenocarcinoma cell lines.1 Ameloblastoma cells with an activating SMO-L412F mutation were insensitive to vismodegib (another SMO antagonist) but BMS-833923 significantly reduced downstream Hedgehog signaling and tumor cell viability.2 In developmental studies BMS-833923 has been characterized as a uniquely effective SMO inhibitor when it was used to show that  Sonic hedgehog is functionally dedicated to ray branching during fin regeneration in zebrafish.3 Orally active.

References/Citations:

  1. Zaidi et al. (2013), Smoothened inhibition leads to decreased proliferation and induces apoptosis in esophageal adenocarcinoma cells; Cancer Invest., 31 480
  2. Nguyen et al. (2022), New Ameloblastoma Cell Lines Enable Preclinical Study of Targeted Therapies; J. Dent. Res., 101 1517
  3. Armstrong et al. (2017), Shh promotes direct interactions between epidermal cells and osteoblast progenitors to shape regenerated zebrafish bone; Development, 144 1165