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Bongkrekic Acid | Inhibits MPT pore opening

Bongkrekic acid (11076-19-0) is a potent inhibitory ligand of the mitochondrial adenine nucleotide translocase (ANT).1 Inhibits mitochondrial permeability transition pore opening.2,3 Delivery of bongkrekic acid to the mitochondria prevents apoptosis in HeLa cells.4

1) Ziegler et al. (1993), The adenine nucleotide translocase modulates oligomycin-induced quenching of pyranine fluorescence in submitochondrial particles; J. Biol. Chem., 268 25320
2) Marchetti et al. (1996), Mitochondrial permeability transition triggers lymphocyte apoptosis; J. Immunol., 157 4830
3) Zamzami et al. (1996), Inhibitors of permeability transition interfere with the disruption of the mitochondrial transmembrane potential during apoptosis; FEBS Lett., 384 53
4) Yamada et al. (2013), Mitochondrial delivery of bongkrekic acid using a MITO-Porter prevents the induction of apoptosis in human HeLa cells; J. Pharm. Sci., 102 1008

Focus Biomolecules reagent supplier, chemical structure of Bongkrekic Acid | Inhibits MPT pore opening | CAS 11076-19-0

Catalog#  10-2751

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Catalog Number:
Inhibits MPT pore opening
Chemical Name:
3-Carboxymethyl-17-methoxy-6,18,21-trimethyldocosa-2,4,8,12,18,20-heptaenedioic acid triammonium salt
Molecular Weight:
Molecular Formula:
C28H38O7 3NH3
Soluble in DMSO (up to 100 mg/ml) or in Water (up to 1 mg/ml).
Physical Properties:
Lyophilized solid
98% by TLC
NMR (Conforms)
Storage Temperature:
Stable for 2 years as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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