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Bongkrekic Acid | Inhibits MPT pore opening

Bongkrekic acid (11076-19-0) is a p potent inhibitory ligand of the mitochondrial adenine nucleotide translocase (ANT)1. Inhibits mitochondrial permeability transition pore opening2,3. Delivery of bongkrekic acid to the mitochondria prevents apoptosis in HeLa cells4.

References/Citations
1) Ziegler et al. (1993), The adenine nucleotide translocase modulates oligomycin-induced quenching of pyranine fluorescence in submitochondrial particles; J. Biol. Chem., 268 25320
2) Marchetti et al. (1996), Mitochondrial permeability transition triggers lymphocyte apoptosis; J. Immunol., 157 4830
3) Zamzami et al. (1996), Inhibitors of permeability transition interfere with the disruption of the mitochondrial transmembrane potential during apoptosis; FEBS Lett., 384 53
4) Yamada et al. (2013), Mitochondrial delivery of bongkrekic acid using a MITO-Porter prevents the induction of apoptosis in human HeLa cells; J. Pharm. Sci., 102 1008

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Focus Biomolecules reagent supplier, chemical structure of Bongkrekic Acid | Inhibits MPT pore opening | CAS 11076-19-0

Catalog#  10-2751

$140.00
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CAS:
11076-19-0
Catalog Number:
10-2751
Activity:
Inhibits MPT pore opening
Chemical Name:
3-Carboxymethyl-17-methoxy-6,18,21-trimethyldocosa-2,4,8,12,18,20-heptaenedioic acid triammonium salt
Molecular Weight:
537.7
Molecular Formula:
C28H38O7 3NH3
Solubility:
Soluble in DMSO (up to 100 mg/ml) or in Water (up to 1 mg/ml).
Physical Properties:
Lyophilized solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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