Bongkrekic acid (11076-19-0) is a p potent inhibitory ligand of the mitochondrial adenine nucleotide translocase (ANT)¹. Inhibits mitochondrial permeability transition pore opening^2,3. Delivery of bongkrekic acid to the mitochondria prevents apoptosis in HeLa cells⁴.

References/Citations
1) Ziegler et al. (1993), The adenine nucleotide translocase modulates oligomycin-induced quenching of pyranine fluorescence in submitochondrial particles; J. Biol. Chem., 268 25320
2) Marchetti et al. (1996), Mitochondrial permeability transition triggers lymphocyte apoptosis; J. Immunol., 157 4830
3) Zamzami et al. (1996), Inhibitors of permeability transition interfere with the disruption of the mitochondrial transmembrane potential during apoptosis; FEBS Lett., 384 53
4) Yamada et al. (2013), Mitochondrial delivery of bongkrekic acid using a MITO-Porter prevents the induction of apoptosis in human HeLa cells; J. Pharm. Sci., 102 1008