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Product Details

BRD-7389 | p90 RSK inhibitor: insulin stimulator

BRD-7389 (376382-11-5) inhibits p90 ribosomal S6 kinase (RSK), IC50 = 1.2, 1.5 and 2.4 μM for RSK3, RSK1 and RSK2 respectively.1 Induces a β-cell-like state in pancreatic α-cells and induces insulin expression.1,2 Increases the endocrine cell content and function of donor human pancreatic islets in culture.1 BRD-7389 blocks muscarinic acetylcholine receptor-stimulated RSK activation and subsequent proliferation of SNU-407 colon cancer cells.3

References/Citations
1) Fomina-Yadlin et al. (2010), Small molecule inducers of insulin expression in pancreatic alpha-cells; Proc. Natl. Acad. Sci. USA, 107 15099
2) Choudhary et al. (2014), Quantitative-proteomic comparison of alpha and Beta cells to uncover novel targets for lineage reprogramming; PLoS One, 9(4) e95194
3) Park and Cho (2012), EGFR and PKC are involved in the activation of ERK1/2 and p90 RSK and the subsequent proliferation of SNU-470 colon caner cells by muscarinic acetylcholine receptors; Mol. Cell. Biochem., 370 191

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BRD-7389 | 376382-11-5 | Structure | Supplier

Catalog#  10-1424

$80.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
376382-11-5
Catalog Number:
10-1424
Activity:
p90 RSK inhibitor: insulin stimulator
Chemical Name:
1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinolone-2,7-dione
Molecular Weight:
366.42
Molecular Formula:
C24H18N2O2
Solubility:
Soluble in DMSO (up to 35 mg/ml).
Physical Properties:
Brown solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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