Brefeldin A | Inhibits intracellular transport

CAS:
20350-15-6
Catalog Number:
10-1071
Activity:
Inhibits intracellular transport
Alternate Names:
Fermentation product from Penicillium brefeldianum
Molecular Weight:
280.37
Molecular Formula:
C16H24O4
Solubility:
Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 25 mg/ml).
Physical Properties:
White solid
Purity:
99% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Available Options

Size:PriceQuantity 
5 mg$38.00
25 mg$100.00

Brefeldin A (20350-15-6) is a specific inhibitor of protein translocation from endoplasmic reticulum to Golgi. Induces apoptosis. Brefeldin A activates sphingomyelin metabolism. Cell permeable.

References/Citations:

1) Fujiwara et al. (1988) Brefeldin A causes disassembly of the Golgi complex and accumulation of secretory proteins in the endoplasmic reticulum; J. Biol. Chem., 263 18545
2) Shao et al. (1996), Brefeldin A is a potent inducer of apoptosis in human cancer cells independently of p53; Exp. Cell Res., 227 190
3) Linardic et al. (1996), Brefeldin A promotes hydrolysis of sphingomyelin; Cell Growth Differ., 7 765

CAS:
20350-15-6
Catalog Number:
10-1071
Activity:
Inhibits intracellular transport
Alternate Names:
Fermentation product from Penicillium brefeldianum
Molecular Weight:
280.37
Molecular Formula:
C16H24O4
Solubility:
Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 25 mg/ml).
Physical Properties:
White solid
Purity:
99% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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