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Product Details

Bromo-PTC | Cruzain Inhibitor

Bromo-PTC is a potent inhibitor of cruzain (IC50 = 100 nM). Cruzain is the major cysteine protease of Trypanosoma cruzi, the protozoan parasite responsible for American trypanosomiasis or Chagas' disease. Cruzain is essential for the replication of the parasite and thus is a new target for antitrypanosomal chemotherapy. Bromo-PTC exhibits trypanocidal activity in cultured host cells without toxicity1.

References/Citations
1) Xaohui et al. (2002), Synthesis and structure-acctivity relationship study of potent trypanocidal thio semicarrbazone inhibitors of the trypanosomal cysteine protease cruzain; J. Med. Chem., 45 2695

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Focus Biomolecules cell signaling reagent supplier, chemical structure of Bromo-PTC | Cruzain inhibitor | CAS 443144-54-5

Catalog#  10-1433

$55.00
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Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
443144-54-5
Catalog Number:
10-1433
Activity:
Cruzain Inhibitor
Chemical Name:
3'-Bromopropiophenone thiosemicarbazone
Molecular Weight:
286.2
Molecular Formula:
C10H12BrN3S
Solubility:
Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 10 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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