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Bromosporine | Pan-bromodomain inhibitor
Bromosporine (1619994-69-2) is a potent pan-Bromodomain (BRD) inhibitor.1 Bromosporine was able to reactivate HIV-1 replication in different latency models.2
References/Citations
1) Picaud et al. (2016), Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia; Sci. Adv. 2 e1600760
2) Pan et al. (2017), The bromodomain and extraterminal domain inhibitor bromosporine synergistically reactivates latent HIV-1 in latently infected cells; Oncotarget 8 94104
Catalog# 10-4030-0005
$80.00
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CAS:
1619994-69-2
Catalog Number:
10-4030
Activity:
Pan-bromodomain inhibitor
Chemical Name:
Ethyl N-[(6-3-Methanesulfonamido-4-methylphenyl)-3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-8-yl]carbamate
Molecular Weight:
404.44
Molecular Formula:
C17H20N6O4S
Solubility:
Soluble in DMSO (up to 25 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% by HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.
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