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Bz-Val-Gly-Arg-AMC | Proteasome substrate

CAS:
87779-49-5
Catalog Number:
10-2969
Activity:
Proteasome substrate
Chemical Name:
Benzoyl-Val-Gly-Arg-(7-amido-4-methylcoumarin)·trifluoroacetate
Molecular Weight:
705.7
Molecular Formula:
C30H37N7O6·CF3COOH
Solubility:
Soluble in DMSO.
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
RT

Bz-VGR-AMC (87779-49-5) may be used for measuring the trypsin-like activity of the 20S proteasome, in combination with Suc-LLVY-AMC (Cat.# 10-2971, for assaying its chymotrypsin-like activity) and Z-LLE-AMC, (for determining its PGPH activity). Fluorogenic substrate. Ex.: 380nm Em.: 460nm.

References/Citations:

1) Gillardon et al. (2007), The 20S proteasome isolated from Alzheimer’s disease brain shows post-translational modifications but unchanged proteolytic activity; J. Neurochem., 101 1483
2) Kim et al. (2002), Navigation inside a protease: substrate selection and product exit in tricorn protease from Thermoplasma acidophilum; J. Mol. Biol., 324 1041
3) Dahlmann et al. (2000), Different proteasome subtypes in a single tissue exhibit different enzymatic properties; J. Mol. Biol., 303 643
4) Lightcap et al. (2000), Proteasome inhibition measurements: clinical application; Clin. Chem., 46 673

Bz-Val-Gly-Arg-AMC | Proteasome substrate is also available in the Cellular Metabolism Library.
CAS:
87779-49-5
Catalog Number:
10-2969
Activity:
Proteasome substrate
Chemical Name:
Benzoyl-Val-Gly-Arg-(7-amido-4-methylcoumarin)·trifluoroacetate
Molecular Weight:
705.7
Molecular Formula:
C30H37N7O6·CF3COOH
Solubility:
Soluble in DMSO.
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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