C-176 | STING Antagonist

C-176 (314054-00-7) is an inhibitor of the signaling molecule STING in mouse cells. It covalently binds to Cys91 of STING preventing activation via blockade of palmitoylation at Cys91. Treatment of Trex-/- mice with C-176 resulted in a significant reduction in serum levels of Type I Interferons and amelioration of systemic inflammation.

References/Citations

1)Haag et al. (2018), Targeting STING with covalent small-molecule inhibitors; Nature 559 269

Weight 0.01 mg
Dimensions 0.01 × 0.01 × 0.01 cm
Size:

10 mg, 50 mg

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CAS:
314054-00-7
Catalog Number:
10-4130
Activity:
STING Antagonist
Chemical Name:
N-(4-Iodophenyl)-5-nitrofuran-2-carboxamide
Molecular Weight:
358.09
Molecular Formula:
C11H7IN2O4
Solubility:
Soluble in DMSO (up to 25 mg/ml)
Physical Properties:
Brown or yellow solid
Purity:
98%
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

C-176 | STING Antagonist

$40.00$175.00

CAS:
314054-00-7
Catalog Number:
10-4130
Activity:
STING Antagonist
Chemical Name:
N-(4-Iodophenyl)-5-nitrofuran-2-carboxamide
Molecular Weight:
358.09
Molecular Formula:
C11H7IN2O4
Solubility:
Soluble in DMSO (up to 25 mg/ml)
Physical Properties:
Brown or yellow solid
Purity:
98%
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
  • 10 mg
  • 50 mg
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