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Product Details

C-DIM 12 | Nurr1 activator; NFkB inhibitor

C-DIM 12 (178946-89-9) activates the orphan nuclear receptor Nurr1 and inhibits bladder cancer growth.1,2 Nurr1 is a suppressor of NFkB-related neuroinflammatory genes in microglia and astrocytes and C-DIM 12 suppresses inflammatory signaling in these cells.3 Displays neuroprotective activity in a mouse model of progressive neurodegeneration with a strong neuroinflammatory component (50 mg/Kg, oral).4


1) Inamoto et al. (2008), 1,1-Bis(3’-indolyl)-1-(p-chlorophenyl)methane activates the orphan nuclear receptor Nurr1 and inhibits bladder cancer growth; Mol Cancer Ther., 7 3825
2) Li et al. (2012), Structure-dependent activation of NR4A2 (Nurr1) by 1,1-bis(3’-indoyl)-1-(aromatic)methane analogs in pancreatic cancer cells; Biochem. Pharmacol., 83 1445
3) De Miranda et al. (2015), The Nurr1 Activator 1,1-Bis(3’-Indolyl)-1-(p-chlorophenyl)Methane blocks Inflammatory Gene Expression in BV-2 Microglial Cells by Inhibiting Nuclear Factor kB; Mol. Pharmacol., 87 1021
4) De Miranda et al. (2013), Neuroprotective efficacy and pharmakinetic behavior of novel anti-inflammatory para phenyl substituted diindolylmethanes ina a mouse model of Parkinson’s disease; J. Pharmacol. Exp. Ther., 345 125

Focus Biomolecules reagent supplier, chemical structure of C-DIM 12 | Nurr1 activator; NFkB inhibitor | CAS 178946-89-9

Catalog#  10-3280-0005

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Catalog Number:
Nurr1 activator; NFkB inhibitor
Chemical Name:
Molecular Weight:
Molecular Formula:
Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 35 mg/ml)
Physical Properties:
Orange solid
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Shipping Code:
Activates the Nurr1 receptor, inhibits bladder cancer growth and displays neuroprotective activity.
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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