C16 | PKR inhibitor
NMR (Conforms)
Available Options
| size : | Price | Quantity | |
|---|---|---|---|
| 5 mg | $75.00 | ||
| 25 mg | $290.00 |
C16 (608512-97-6) inhibits RNA-dependent protein kinase (PKR, IC50 = 210 nM).1 Inhibits ER stress-induced neuronal damage.2 Reduces brain PKR activation in vivo.3 Prevents apoptosis and IL-1β production in an acute excitotoxic and neuroinflammatory rat model.4 Prevents β-amyloid peptide-induced inflammation in primary murine mixed co-cultures.5 Cell permeable.
References/Citations:
1) Jammi et al. (2003), Small molecule inhibitors of the RNA-dependent protein kinase; Biochem. Biophys. Res. Commun., 308 50
2) Shimazawa et al. (2007), Involvement of double-stranded RNA-dependent protein kinase in ER stress-induced retinal neuron damage; Ophthalmol. Vis. Sci., 48 3729
3) Ingrand et al. (2007), The oxindole/imidazole derivative C16 reduces in vivo brain PKR activation; FEBS Lett. 581 4473
4) Tronel et al. (2014), The specific PKR inhibitor C16 prevents apoptosis and IL-1β production in an acute excitotoxic rat model with a neuroinflammatory component; Neurochem. Int. 64 73
5) Couturier et al. (2011) Prevention of the β-amyloid peptide-induced inflammatory process by inhibition of double-stranded RNA-dependent protein kinase in primary murine mixed co-cultures; Neuroinflammation, 8 72
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
C16 (608512-97-6) inhibits RNA-dependent protein kinase (PKR, IC50 = 210 nM).1 Inhibits ER stress-induced neuronal damage.2 Reduces brain PKR activation in vivo.3 Prevents apoptosis and IL-1β production in an acute excitotoxic and neuroinflammatory rat model.4 Prevents β-amyloid peptide-induced inflammation in primary murine mixed co-cultures.5 Cell permeable.
References/Citations:
1) Jammi et al. (2003), Small molecule inhibitors of the RNA-dependent protein kinase; Biochem. Biophys. Res. Commun., 308 50
2) Shimazawa et al. (2007), Involvement of double-stranded RNA-dependent protein kinase in ER stress-induced retinal neuron damage; Ophthalmol. Vis. Sci., 48 3729
3) Ingrand et al. (2007), The oxindole/imidazole derivative C16 reduces in vivo brain PKR activation; FEBS Lett. 581 4473
4) Tronel et al. (2014), The specific PKR inhibitor C16 prevents apoptosis and IL-1β production in an acute excitotoxic rat model with a neuroinflammatory component; Neurochem. Int. 64 73
5) Couturier et al. (2011) Prevention of the β-amyloid peptide-induced inflammatory process by inhibition of double-stranded RNA-dependent protein kinase in primary murine mixed co-cultures; Neuroinflammation, 8 72
Related products
-
ZM-306416 | VEGFR kinase inhibitor
From $60.00CAS:196603-47-1Catalog Number:10-1019Activity:VEGFR kinase inhibitorChemical Name:4-[(4′-Chloro-2′-fluoro)phenylamino]-6,7-dimethoxyquinazoline hydrochlorideMolecular Weight:370.12Molecular Formula:C16H13ClFN3O2·HClSolubility:Soluble in DMSO (up to 5 mg/ml).Physical Properties:White solidPurity:98% by TLCStorage Temperature:RTStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT -
AS-041164 | PI3Kgamma inhibitor
From $54.00CAS:6318-41-8Catalog Number:10-1035Activity:PI3Kγ inhibitorChemical Name:5-(1,3-Benzodioxol-5-yl)methylidene-1,3-thiazolidine-2,4-dioneMolecular Weight:249.24Molecular Formula:C11H7NO4SSolubility:Soluble in DMSO (up to 25 mg/ml).Physical Properties:Yellow solidPurity:98% by TLCStorage Temperature:RTStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT -
Sunitinib malate | VEGFR, PDGFR kinase inhibitor
From $60.00CAS:341031-54-7Catalog Number:10-1078Activity:VEGFR, PDGFR kinase inhibitorAlternate Names:SU-11248Chemical Name:N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide malateMolecular Weight:532.57Molecular Formula:C22H27FN4O4 C4H6O5Solubility:Soluble in DMSO (up to 13 mg/ml).Physical Properties:Orange solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
