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Product Details

C22 Ceramide | MCSR inhibitor

C22 Ceramide is a long-chain ceramide containing behenic acid. Mitochondrial-to-cytosolic stress response (MCSR) is a recently identified stress response which can be induced by increased synthesis of fatty acids. C22-ceramide is an endogenous signaling lipid which specifically inhibits MCSR with no effect on unfolded protein responses within the mitochondria.1 Hearts overexpressing Acyl CoA synthetase1 contain elevated levels of C22-ceramide.2


1) Kim et al. (2016), Lipid Biosynthesis Coordinates a Mitochondrial-to-Cytosolic Stress Response; Cell, 166 1539
2) Goldenberg et al. (2016), Acyl-CoA synthase-1 links facilitated long chain fatty acid uptake to intracellular metabolic trafficking differently in hearts of male vs. female mice; J. Mol. Cell. Cardiol., 94 1

Focus Biomolecules cell signaling reagent supplier, chemical structure of C22 Ceramide | MCSR inhibitor | CAS 27888-44-4

Catalog#  10-1615

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Catalog Number:
MCSR inhibitor
Molecular Weight:
Molecular Formula:
Soluble in DMSO (up to 12 mg/ml with warming) or in Ethanol (up to 10 mg/ml with warming
Physical Properties:
White solid
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
Endogenous signaling lipid which specifically inhibits mitochondrial-to-cytosolic stress response (MCSR) with no effect on unfolded protein responses within the mitochondria
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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