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C22 Ceramide | MCSR inhibitor

CAS:
869501-30-4
Catalog Number:
10-1615
Activity:
MCSR inhibitor
Molecular Weight:
622.06
Molecular Formula:
C40H79NO3
Solubility:
Soluble in DMSO (up to 12 mg/ml with warming) or in Ethanol (up to 10 mg/ml with warming
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

C22 Ceramide (86950-30-14) is a long-chain ceramide containing behenic acid. Mitochondrial-to-cytosolic stress response (MCSR) is a recently identified stress response which can be induced by increased synthesis of fatty acids. C22-ceramide is an endogenous signaling lipid which specifically inhibits MCSR with no effect on unfolded protein responses within the mitochondria.1 Hearts overexpressing Acyl CoA synthetase1 contain elevated levels of C22-ceramide.2

References/Citations:

1) Kim et al. (2016), Lipid Biosynthesis Coordinates a Mitochondrial-to-Cytosolic Stress Response; Cell, 166 1539
2) Goldenberg et al. (2016), Acyl-CoA synthase-1 links facilitated long chain fatty acid uptake to intracellular metabolic trafficking differently in hearts of male vs. female mice; J. Mol. Cell. Cardiol., 94 1

C22 Ceramide | MCSR inhibitor is also available in the Cellular Metabolism Library.
CAS:
869501-30-4
Catalog Number:
10-1615
Activity:
MCSR inhibitor
Molecular Weight:
622.06
Molecular Formula:
C40H79NO3
Solubility:
Soluble in DMSO (up to 12 mg/ml with warming) or in Ethanol (up to 10 mg/ml with warming
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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