C2230 | Cav2.2 channel blocker

C2230 chemical structure

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25 mg$225.00
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C2230 (882243-88-1) is a novel Cav2.2 channel blocker (IC50 = 1.3 µM @ -50 mV; 10.2 µM @ -80 mV) with a unique binding mode (no GPCR-mediated inhibition).  It displays preferential binding to the inactive state of the channel.  C2230 is active in both rat and human DRG neurons.  Active in rat models of neuropathic pain and mouse models of osteoarthritis.  C2230 does not affect somatosensation or motor and cardiac function.

References/Citations:

  1. Tang et al. (2024), C2230, a preferential use- and state-dependent Cav2.2 channel blocker, mitigates pain behaviors across multiple pain models; J. Clin. Invest. Dec 10 e177429
882243-88-1, C-2230, C2230, C2230 supplier, Cav2.2 blocker

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Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

C2230 (882243-88-1) is a novel Cav2.2 channel blocker (IC50 = 1.3 µM @ -50 mV; 10.2 µM @ -80 mV) with a unique binding mode (no GPCR-mediated inhibition).  It displays preferential binding to the inactive state of the channel.  C2230 is active in both rat and human DRG neurons.  Active in rat models of neuropathic pain and mouse models of osteoarthritis.  C2230 does not affect somatosensation or motor and cardiac function.

References/Citations:

  1. Tang et al. (2024), C2230, a preferential use- and state-dependent Cav2.2 channel blocker, mitigates pain behaviors across multiple pain models; J. Clin. Invest. Dec 10 e177429