C8-Dihydroceramide | Negative control for C8-Ceramide

c8-dihydroceramide chemical structure

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C8-dihydroceramide (C8-dhCer; 145774-33-0) is a cell permeable, saturated ceramide analog. Unlike C8-Cer it does not stimulate ceramide-activated protein kinase1 nor does it induce apoptosis2 and therefore may be used as a negative control in experiments focused on the cellular activity of C8-ceramide3. C8-dhCer is a substrate for dihydroceramide desaturase.4

References/Citations:

  1. Mathias et al. (1991), Characterization of a ceramide-activated protein kinase: stimulation by tumor necrosis factor alpha; Proc. Natl. Acad. Sci. USA, 88 109
  2. Jarvis et al. (1994), Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway; Proc. Natl. Acad. Sci. USA, 91 73
  3. Struckhoff al. (2004), Novel ceramide analogs as potential chemotherapeutic agents in breast cancer; J. Pharmacol. Exp. Ther., 309 523
  4. Rahmaniyan al. (2011), Identification of dihydroceramide desaturase as a direct in vitro target for fenretinide; J. Biol. Chem., 286 24754
145774-33-0, C8-dihydroceramide, C8-Dihydroceramide supplier, C8dihydroceramide
Alternate Name:
C8-dhCer

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C8-dihydroceramide (C8-dhCer; 145774-33-0) is a cell permeable, saturated ceramide analog. Unlike C8-Cer it does not stimulate ceramide-activated protein kinase1 nor does it induce apoptosis2 and therefore may be used as a negative control in experiments focused on the cellular activity of C8-ceramide3. C8-dhCer is a substrate for dihydroceramide desaturase.4

References/Citations:

  1. Mathias et al. (1991), Characterization of a ceramide-activated protein kinase: stimulation by tumor necrosis factor alpha; Proc. Natl. Acad. Sci. USA, 88 109
  2. Jarvis et al. (1994), Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway; Proc. Natl. Acad. Sci. USA, 91 73
  3. Struckhoff al. (2004), Novel ceramide analogs as potential chemotherapeutic agents in breast cancer; J. Pharmacol. Exp. Ther., 309 523
  4. Rahmaniyan al. (2011), Identification of dihydroceramide desaturase as a direct in vitro target for fenretinide; J. Biol. Chem., 286 24754