CAIF | FUT8 inhibitor

CAS:
 N/A
Catalog Number:
 10-4406

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10 mg$90.00
50 mg$340.00
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CAIF is a covalent allosteric inhibitor of fucosyltransferase 8 (FUT8; IC50 = 5.7 µM). Selective over FUT3 and FUT4.  FUT8 in involved in tumor invasion, metastasis, and immune evasion as well as antitumor immunity and drug resistance. It displayed minimal cytotoxicity and displayed efficacy in inhibiting core fucosylation in multiple cancer cell lines.  CAIF also suppressed cancer cell migration and invasion in multiple tumor models.

References/Citations:

  1. Jiang et al. (2026) Exploiting human fucosyltransferase 8 allostery with a covalent inhibitor for core fucosylation suppression; Nat. Commun. 17 2607
CAIF, CAIF supplier, fucosyltransferase 8 inhibitor, FUT8 inhibitor
CAS:
N/A
Catalog Number:
10-4406
Activity:
Fucosyltransferase 8 inhibitor
Chemical Names:
1-(18-((2,5-Dioxopyrrolidin-1-yl)oxy)-2,3-dimethyl-1H-imidazol-3-ium bromide
Molecular Weight:
556.59
Molecular Formula:

C27H46BrN3O4

Solubility:
Soluble in DMSO (> 100 mg/ml)
Physical Properties:
White solid
Purity:

>98% TLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for up to 1 year when stored as supplied @ -20°C. Solutions in anhydrous DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

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Product Data Sheet:

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Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

CAIF is a covalent allosteric inhibitor of fucosyltransferase 8 (FUT8; IC50 = 5.7 µM). Selective over FUT3 and FUT4.  FUT8 in involved in tumor invasion, metastasis, and immune evasion as well as antitumor immunity and drug resistance. It displayed minimal cytotoxicity and displayed efficacy in inhibiting core fucosylation in multiple cancer cell lines.  CAIF also suppressed cancer cell migration and invasion in multiple tumor models.

References/Citations:

  1. Jiang et al. (2026) Exploiting human fucosyltransferase 8 allostery with a covalent inhibitor for core fucosylation suppression; Nat. Commun. 17 2607

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